Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2243658..2244346 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN146_RS10500 Protein ID WP_003409958.1
Coordinates 2243658..2244077 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN146_RS10505 Protein ID WP_003409968.1
Coordinates 2244086..2244346 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS10475 2239008..2239286 - 279 WP_003907828.1 hypothetical protein -
JN146_RS10480 2239416..2240063 - 648 WP_003909553.1 PE family protein -
JN146_RS10485 2240843..2241442 + 600 WP_234776458.1 hypothetical protein -
JN146_RS10490 2241588..2242274 - 687 WP_003909555.1 immunoprotective protein Mpt64 -
JN146_RS10495 2242465..2243433 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN146_RS10500 2243658..2244077 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN146_RS10505 2244086..2244346 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN146_RS10510 2244489..2246165 + 1677 WP_244748530.1 PecA family PE domain-processing aspartic protease -
JN146_RS10515 2246153..2246806 - 654 WP_003409976.1 cutinase Cfp21 -
JN146_RS10520 2246921..2247151 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN146_RS10525 2247236..2248147 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN146_RS10530 2248256..2248855 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189189 WP_003409958.1 NZ_CP069067:c2244077-2243658 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189189 NZ_CP090687:c1369481-1369197 [Burkholderia multivorans]
ATGACCAACTACACCGAGTTCGATGCGGCCGATTACCTCGACAACGATGAGGCGGTCGCGGAATTCCTCGCCGTCGCGGC
AGAGGACCCGAATCCTGACGTGTTCCTCGCGGCCGTCGCTGCGGTCGCGCGGGCGCGCGGTATGACGAAAGTTGCGGCAG
CCGCCGGCGTCGGACGCGTCGCGCTTCACAAGGCACTGACGCCCGGCGCGCACCCGCGCTACGAAACCGTGCAGAAAATC
ATCCGGTCGCTCGGCCTGCGCATGAGCTTCACGGTCGCGCACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189189 WP_003409968.1 NZ_CP069067:c2244346-2244086 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189189 NZ_CP090687:c1369778-1369485 [Burkholderia multivorans]
ATGGTTACTTTGCTGCGATCCACGGAGTTCAACGATTGGCTTGCCAACCTGCGCGATCAGCGCGGCAAGGCCCGAATCGC
AGCCCGCCTGATCAGCGCGCAACTCGGCAACTTCGGCGAGTACCGTGTGCTCGACGAAGGGGTCTGCGAACTGAAGATCG
ATTTCGGTCCGGGCTACCGCGTGTATTACGTTCGACGCGGCGAAGTGGTCTACCTCCTTCTGTGCGGCGGCGACAAGTCA
ACGCAACGGAAGGACATCAAGCCCGTGCAGATGGCGCGCGAACTGAAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References