Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1237160..1237791 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag JN146_RS05920 Protein ID WP_003405820.1
Coordinates 1237160..1237471 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag JN146_RS05925 Protein ID WP_003405836.1
Coordinates 1237471..1237791 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS05900 1232642..1234066 - 1425 WP_003405805.1 class II fumarate hydratase -
JN146_RS05905 1234097..1235185 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
JN146_RS05910 1235241..1235885 + 645 WP_244748910.1 DUF4245 domain-containing protein -
JN146_RS05915 1235892..1237048 - 1157 Protein_1166 AI-2E family transporter -
JN146_RS05920 1237160..1237471 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
JN146_RS05925 1237471..1237791 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
JN146_RS05930 1237801..1239337 + 1537 Protein_1169 carboxylesterase/lipase family protein -
JN146_RS05935 1239344..1240456 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
JN146_RS05940 1240466..1240723 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
JN146_RS05945 1240713..1241960 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
JN146_RS05950 1241957..1242595 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T189176 WP_003405820.1 NZ_CP069067:c1237471-1237160 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T189176 NZ_CP090681:1777233-1777844 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCTGAACGCTTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGTGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGAGAAGAACATGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTGACGAGCTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGACGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACAAACGTCATCGCAAACACAAACGCGCACGCACCGCGCATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT189176 WP_003405836.1 NZ_CP069067:c1237791-1237471 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT189176 NZ_CP090681:1776545-1777102 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCACACGCCGCCGCTGGGCCCGCAGCTAAGACGCTGGCGCCTGCTACATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGCCTGCTCGCCGCGCGCCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGACTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGGACGAACGCATCGCGCGTCGTGCCG
ATCCATCGCAGCCGATGCCGCTGGACCCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References