Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 759330..760018 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN146_RS03515 Protein ID WP_003403386.1
Coordinates 759330..759767 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag JN146_RS03520 Protein ID WP_003911263.1
Coordinates 759764..760018 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS03485 755581..756591 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN146_RS03490 756979..757362 - 384 WP_003403365.1 ribonuclease VapC6 -
JN146_RS03495 757457..757612 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JN146_RS03500 757688..758404 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN146_RS03505 758680..758988 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN146_RS03510 758975..759220 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN146_RS03515 759330..759767 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN146_RS03520 759764..760018 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
JN146_RS03525 760132..762495 + 2364 WP_003403397.1 arylsulfatase AtsD -
JN146_RS03530 762558..762884 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN146_RS03535 762796..763134 + 339 WP_003403405.1 PIN domain-containing protein -
JN146_RS03540 763131..763304 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189171 WP_003403386.1 NZ_CP069067:c759767-759330 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189171 NZ_CP090681:1031932-1032507 [Burkholderia multivorans]
ATGACGCATTCGCCATTTACGGCGATCTACGATGCCTGTGTGCTTTATCCCGCGCCGCTTCGCGATTTCCTGATGCGGCT
GGCGTTGAGTGGATGTTTCCGGGCGCGGTGGAGCGCACATATTACCGACGAGTGGAAGCGCAATCTGTTGGACAACCGTC
CGGATTTGACAGCGGAACAGCTTGATCGAACGTCAAGTTTGATGGATCGAGCGATACCGGATGCCGTCGTGACCGGTTAT
GAATCGTTGATTGCCGGGCTTGTTCTCCCGGATGCCGACGATCGTCACGTGCTTGCCGCTGCAATCCGTTGCAACGCCAG
CGTGATCGTGACGTTCAATCGAAAGGACTTTCCGGAAGAGGCGTTGTTGCCGTACGGCATCGAGGCCCAGCATCCAGACG
AGTTCGTCGATAATCTTTTCGACCTCGAACCCGCGGTGGTCGTTGCGGCCGCGCGACGACAGCGAGAGGCACTTAAACAA
CCACCGTTGACCGCAGACCGGTACCTCGAGATTTTGCGACGACAAGGCATGGTGCAGACGTGTCAGTCGCTCGACGCCTA
TCGAGCACTTCTTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT189171 WP_003911263.1 NZ_CP069067:c760018-759764 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT189171 NZ_CP090681:1031468-1031935 [Burkholderia multivorans]
ATGCATCACGCCACGACACCCGACATGATCTTGCCCGTCGAGCGCGAGATGCAGGCGGCCGTCGAGGGGCAACGCATGCT
GGCGGCTTATCTCGCAACACGGACCGATACGCAGCGCATTCAGATTTTTGATGACGAGAACCGAGCCCATCAGGTCGAGC
TGCCGACGTCCGCACTTCGTCTGCTGGTGGATATTCTCGCGGAATTGGCGGACGGAAACGCTGTCAAGGTTGTGCCGGTT
CATGCGGAATTGACGACGCAGGAAGCGGCAGATCTGCTCAATGTCTCCCGCCCGCATCTGATCAAGCTGCTTGAGTCGAA
TGCATTGCCCTATCACCGGACGGGCAAGCATCGGCGCGTGCGGTTTTCGGATCTGATGCGCTACAAGGCTGAGCGCGACC
AAGAGAGTGCTGACGCAATGGAAGAGCTGGGCAAGCAGGCACAGGCGCTGCGGATGGGCTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References