Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 681167..681786 Replicon chromosome
Accession NZ_CP069067
Organism Mycobacterium tuberculosis strain N1268

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag JN146_RS03085 Protein ID WP_003403047.1
Coordinates 681379..681786 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag JN146_RS03080 Protein ID WP_003403039.1
Coordinates 681167..681382 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN146_RS03070 679695..680453 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
JN146_RS03075 680582..681073 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
JN146_RS03080 681167..681382 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
JN146_RS03085 681379..681786 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
JN146_RS03090 681846..682532 - 687 WP_003909258.1 LpqN/LpqT family lipoprotein -
JN146_RS03095 682686..685319 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T189161 WP_003403047.1 NZ_CP069067:681379-681786 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T189161 NZ_CP090678:c969254-968889 [Burkholderia multivorans]
ATGGTAAAAGCTCTCTTCGACACCAACATCCTGATCGACTATCTGAGCGGCGTGGAGTCGGCCCGCCTGGAGCTCGGCCG
CTACGACCACCGTGCGATCAGCACCATTACGTGGATGGAAGTCCTGGTCGGTACGACCGCAGATGACGAAGGCCCGATTC
GCGCGTGGCTCTCGTCGTTCGACGTGATCCCGCTCGACAGTACGGTTGCCGACCGCGCCGTGACCATTCGCAAGGAACGG
CGCATTCGTCTGCCCGACGCGATCGTCTGGGCATCAGCGCAGGTGAACGGACTCCTGCTCGTGTCGCGCAACACGAAAGA
CTTTCCCTCGACGGAACCCGGCATCCGGGTGCCTTACCAGATCTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT189161 WP_003403039.1 NZ_CP069067:681167-681382 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT189161 NZ_CP090678:c969466-969248 [Burkholderia multivorans]
ATGAGCCGAGTCTTGGTGGATCTGTCGGATGGCCAGCTCGACGAGCTGGCCGTCATCGTCGAGACTGAGCATCGTCCTCG
CGCCGCGATCATTCGCGATGCGATTGACGCCTACATCGCCCTACACAAGCGCCCGCTCGCCGACGATGTCTTCGGCCTCT
GGAAAGACCGCGCCGTCGACGGGCTCGCTTATCAGGAAAAACTGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References