Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3778658..3779325 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag JN147_RS17685 Protein ID WP_003417916.1
Coordinates 3778658..3779050 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag JN147_RS17690 Protein ID WP_003912214.1
Coordinates 3779050..3779325 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS17670 3774028..3775866 - 1839 WP_244747341.1 1-deoxy-D-xylulose-5-phosphate synthase -
JN147_RS17675 3775863..3776852 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN147_RS17680 3776852..3777904 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
JN147_RS17685 3778658..3779050 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
JN147_RS17690 3779050..3779325 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN147_RS17695 3779507..3780878 + 1372 Protein_3500 ISNCY family transposase -
JN147_RS17700 3781068..3783329 + 2262 WP_031667118.1 PE family protein -
JN147_RS17705 3783400..3784272 - 873 WP_003910771.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3780201..3780878 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T189153 WP_003417916.1 NZ_CP069066:c3779050-3778658 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T189153 NZ_CP090677:c877347-877048 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCTCGTGCACGCGGCATGTCGC
AGGTCGCACGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGCCGCCAAGGCTGCCGCGTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT189153 WP_003912214.1 NZ_CP069066:c3779325-3779050 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT189153 NZ_CP090677:c877689-877351 [Burkholderia cenocepacia]
ATGGTTTACACATTGCAATGCATGCCCTACAGTCCTCCTGCATTCGGCATCCGGACCACCGACGTCTTCGACGCCTGGTT
TGCCGGCCTGCCCGATCGCCTCGCCAAACGCCGCATCCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGTATCGACCACGGCCCGGGCTATCGCGTCTATGACGTGAGGCGCGGA
ACGATATGGGTCATCCTGCTGTGCGGCGGAGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGC
GTACCTCGACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References