Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2797720..2798372 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN147_RS13070 Protein ID WP_003412752.1
Coordinates 2797947..2798372 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JN147_RS13065 Protein ID WP_003412749.1
Coordinates 2797720..2797941 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS13050 2795960..2796166 - 207 WP_003899347.1 hypothetical protein -
JN147_RS13055 2796302..2796925 + 624 WP_003900858.1 TIGR00725 family protein -
JN147_RS13060 2796915..2797667 + 753 WP_003901416.1 hypothetical protein -
JN147_RS13065 2797720..2797941 + 222 WP_003412749.1 antitoxin Antitoxin
JN147_RS13070 2797947..2798372 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN147_RS13075 2798395..2799576 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
JN147_RS13080 2799573..2800619 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN147_RS13085 2800630..2801733 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN147_RS13090 2801992..2802813 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN147_RS13095 2802810..2803367 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T189137 WP_003412752.1 NZ_CP069066:2797947-2798372 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T189137 NZ_CP090650:c171342-171049 [Pseudomonas aeruginosa]
ATGACTGAGACCTTTACCGATTTCGACCCCGCCGAGTACCTCACCAGCCCCGAGGCCATTGCGGAGTTTATGAGCGATGC
CCTGGAAACCGGCGATGCCGGTTATATCGCCAAGGCCATGGGGGTGGTGGCGCGCGCCAGAGGCATGACCGAGCTGGCCA
GGGAAACCGGCCTGTCCCGCGAGCAGCTGTACCGTTCCTTCAGCGAGCACGGCAATCCCACGCTGAAAACCATGCTCGCC
GTCATGAAGGCGCTGGGCGTCGATATGGCTGCTCGCCCGCATATCGCGCACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT189137 WP_003412749.1 NZ_CP069066:2797720-2797941 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT189137 NZ_CP090650:c171637-171335 [Pseudomonas aeruginosa]
ATGAAAAAGATCGAATCCAGCAAGTTCCGAACTTGGCTGAAGAAGCTCAAGGACGACACCGGCAGGGCCCGTATCGTGGC
GCGGATCAATCGGCTGATGGAGGGCTTGCCGGGCGATGTCGCTCCGGTCGGGCACGGCGTCAGCGAGCTACGGATTCACT
ACGGCCCCGGCTACCGGGTGTATTTTCACCAGCAAGGCGACACCCTGGTGATACTGCTCTGCGGTGGCGACAAGGGCAGC
CAGAGCCGTGACATCGAGGCCGCCCACCAGATTCTGCAGGCGTGGAGAGCGCAACATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References