Detailed information of TA system TA189136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2396411..2396940
• Replicon: chromosome
• Accession: NZ_CP069066
• Organism: Mycobacterium tuberculosis strain N1201

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JN147_RS11185
• Protein ID: WP_244747277.1
• Coordinates: 2396411..2396728 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: JN147_RS11190
• Protein ID: WP_003411127.1
• Coordinates: 2396725..2396940 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN147_RS11155	2391432..2392508	+	1077	WP_003411110.1	hypothetical protein	-
JN147_RS11160	2392505..2392786	+	282	WP_003411112.1	DUF5703 family protein	-
JN147_RS11165	2392822..2393895	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
JN147_RS11170	2393900..2394430	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
JN147_RS11175	2394478..2395824	-	1347	WP_003910508.1	M20/M25/M40 family metallo-hydrolase	-
JN147_RS11185	2396411..2396728	-	318	WP_244747277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN147_RS11190	2396725..2396940	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
JN147_RS11195	2397195..2398253	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
JN147_RS11200	2398383..2398739	-	357	WP_003411130.1	hypothetical protein	-
JN147_RS11205	2398834..2399616	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
JN147_RS11210	2399884..2400174	-	291	WP_003900476.1	YggT family protein	-
JN147_RS11215	2400336..2400992	-	657	WP_003411133.1	cell division protein SepF	-
JN147_RS11220	2401058..2401834	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12328.88 Da
• Isoelectric Point: 6.4831

>T189136 WP_244747277.1 NZ_CP069066:c2396728-2396411 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVSYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T189136 NZ_CP090649:c5688428-5688150 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT189136 WP_003411127.1 NZ_CP069066:c2396940-2396725 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT189136 NZ_CP090649:c5688138-5687833 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4FAJ4