Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2218015..2218703 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN147_RS10335 Protein ID WP_003409958.1
Coordinates 2218015..2218434 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN147_RS10340 Protein ID WP_003409968.1
Coordinates 2218443..2218703 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189129 WP_003409958.1 NZ_CP069066:c2218434-2218015 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189129 NZ_CP090649:c1107296-1107003 [Pseudomonas aeruginosa]
ATGACTGAGACCTTTACCGATTTCGACCCCGCCGAGTACCTCACCAGCCCCGAGGCCATTGCGGAGTTTATGAGCGATGC
CCTGGAAACCGGCGATGCCGGTTATATCGCCAAGGCCATGGGGGTGGTGGCGCGCGCCAGAGGCATGACCGAGCTGGCCA
GGGAAACCGGCCTGTCCCGCGAGCAGCTGTACCGTTCCTTCAGCGAGCACGGCAATCCCACGCTGAAAACCATGCTCGCC
GTCATGAAGGCGCTGGGCGTCGATATGGCTGCTCGCCCGCATATCGCGCACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189129 WP_003409968.1 NZ_CP069066:c2218703-2218443 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189129 NZ_CP090649:c1107591-1107289 [Pseudomonas aeruginosa]
ATGAAAAAGATCGAATCCAGCAAGTTCCGAACTTGGCTGAAGAAGCTCAAGGACGACACCGGCAGGGCCCGTATCGTGGC
GCGGATCAATCGGCTGATGGAGGGCTTGCCGGGCGATGTCGCTCCGGTCGGGCACGGCGTCAGCGAGCTACGGATTCACT
ACGGCCCCGGCTACCGGGTGTATTTTCACCAGCAAGGCGACACCCTGGTGATACTGCTCTGCGGTGGCGACAAGGGCAGC
CAGAGCCGTGACATCGAGGCCGCCCACCAGATTCTGCAGGCGTGGAGAGCGCAACATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References