Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2209001..2209545 | Replicon | chromosome |
| Accession | NZ_CP069066 | ||
| Organism | Mycobacterium tuberculosis strain N1201 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JN147_RS10275 | Protein ID | WP_003409896.1 |
| Coordinates | 2209001..2209297 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JN147_RS10280 | Protein ID | WP_003409899.1 |
| Coordinates | 2209294..2209545 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN147_RS10220 | 2204034..2204384 | - | 351 | WP_003910480.1 | hypothetical protein | - |
| JN147_RS10225 | 2204395..2205297 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| JN147_RS10230 | 2205318..2205509 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN147_RS10235 | 2205510..2205806 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN147_RS10240 | 2206046..2206261 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN147_RS10245 | 2206258..2206569 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN147_RS10250 | 2206543..2207064 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN147_RS10255 | 2207039..2207416 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JN147_RS10260 | 2207458..2207907 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JN147_RS10265 | 2207904..2208449 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN147_RS10270 | 2208338..2208952 | - | 615 | WP_003910483.1 | hypothetical protein | - |
| JN147_RS10275 | 2209001..2209297 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JN147_RS10280 | 2209294..2209545 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JN147_RS10285 | 2209532..2210026 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN147_RS10290 | 2210186..2210593 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN147_RS10295 | 2210597..2210869 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN147_RS10300 | 2210902..2212122 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JN147_RS10305 | 2213021..2213326 | + | 306 | Protein_2037 | ABC transporter permease | - |
| JN147_RS10310 | 2213322..2213402 | + | 81 | Protein_2038 | hypothetical protein | - |
| JN147_RS10315 | 2213510..2214358 | + | 849 | WP_003910485.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T189128 WP_003409896.1 NZ_CP069066:c2209297-2209001 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T189128 NZ_CP090649:c147390-147109 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT189128 WP_003409899.1 NZ_CP069066:c2209545-2209294 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT189128 NZ_CP090649:c147614-147387 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |