Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 839239..839948 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag JN147_RS03980 Protein ID WP_003403837.1
Coordinates 839520..839948 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A109SUH0
Locus tag JN147_RS03975 Protein ID WP_003910195.1
Coordinates 839239..839496 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS03970 836907..839148 + 2242 Protein_786 PE family protein -
JN147_RS03975 839239..839496 + 258 WP_003910195.1 ribbon-helix-helix protein, CopG family Antitoxin
JN147_RS03980 839520..839948 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
JN147_RS03985 840029..840166 - 138 WP_003403839.1 hypothetical protein -
JN147_RS03995 840325..840570 + 246 WP_003403841.1 hypothetical protein -
JN147_RS04000 840639..841523 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
JN147_RS04005 841534..842706 - 1173 WP_003910196.1 acyl-CoA dehydrogenase family protein -
JN147_RS04010 842713..844245 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T189113 WP_003403837.1 NZ_CP069066:839520-839948 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T189113 NZ_CP090644:141926-142336 [Burkholderia contaminans]
ATGACGCTGTACCTGCTCGATACCAACATTTTGTCGAACGTGATCCGCGACCCGCGCGGCGCATGCGCCACCCGGATTGG
AGAAACGCCGCCCGAACAAGTGTGCACCTCGATCATCGTGGCCGCGGAATTGCGGTTCGGCGTCTGGAAGCGTGGCTCGT
CAACGCTCGCGCAGCGCGTCGAGCAGCTGCTCGCAAGCCTGACCGTGTTGCCGCTGCAACCGGACGCGGACCGCTGCTAC
GGGCGGTTGCGGGCCGAGCTCGAGAAGCAAGGCCAGTTGATCGACGCCAACGACATGCTGATCGCCGCGCATGCGCTGGC
CGTCGACGCCGTGCTGGTCACGGACAACACGGCTGAATTCACCCGTATCGCGGGGCTGCCGGTCGAAAACTGGCTGCGGC
CGGCGACGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9072.20 Da        Isoelectric Point: 10.6530

>AT189113 WP_003910195.1 NZ_CP069066:839239-839496 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTGPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT189113 NZ_CP090644:141687-141929 [Burkholderia contaminans]
ATGCCAAACCATGACACCCGCCACGCGCGCCTGTTCCGCAACGGGCGGAGCCAGGCCGTGCGGATCCCGCGCGAATTCGA
ACTGCCGGTGTCGGAGGTCACCATCCACCGGGAAGGTCGCCGCTTGATCATTGAGCCCGTAGAGGCCGCGCCCTTGCGCG
AGCTGTTCGCCCAATGGACCCCGCTGGACGAGATCTTCCCGGACATCGAGGACCTTCCGCCTGAACCGGTCGATATCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB A0A109SUH0

References