Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 753300..754092 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN147_RS03495 Protein ID WP_003403386.1
Coordinates 753655..754092 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag JN147_RS03490 Protein ID WP_003403381.1
Coordinates 753300..753545 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189111 WP_003403386.1 NZ_CP069066:c754092-753655 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189111 NZ_CP090644:65594-65887 [Burkholderia contaminans]
ATGAGAATCGAGCAGACAGACGACTTCGCGAAATGGTTGCGCGGCCTACGCGATCACATCGCGCGCGCGCAGATCGCCAA
GCGGATTCAACGGCTCGCGCGCGGCCAATATGGGGACATGAAGCCGGTGGGTGCCGGAGTGAGCGAAATGCGCGTGCACG
TCGGCCCCGGCTATCGCGTCTACTTTGTCCAACGAGGCTCAACGCTCGTCGTCCTGCTATGCGGTGGCGACAAGTCAACG
CAGCAGCGCGACATTGAGCGTGCTATCGCGCTTTCGGCGCAATTGGGAGATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT189111 WP_003403381.1 NZ_CP069066:c753545-753300 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT189111 NZ_CP090644:65889-66188 [Burkholderia contaminans]
ATGGGTATCAAGACAACGCCGTTCGATGCGGCCGAATACCTCGACACGCCCGAGGCGCAGGCCGAATATCTGCGGATTTC
GTTCGAGACCGGCGATTCCGCCGACATTCAGGAAGCCATCGGCACCGTGGCGCGTGCGCGTGGCATGACGCAGATTGCGC
GCGACGCGGGCGTCGGCCGCGAAAGCCTCTACAAAGCGCTGGACGAGCACGGCAACCCGGAATTCGCGACGATCCTGCGT
GTTGTGCGCGCGCTCGGCCTCACGTTGACCGTGACGACGCCCGTACACGAGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References