Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751304..751937 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JN147_RS03470 Protein ID WP_003403365.1
Coordinates 751304..751687 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JN147_RS03475 Protein ID WP_003403368.1
Coordinates 751782..751937 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS03445 746596..747132 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN147_RS03450 747169..747561 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JN147_RS03455 747554..748249 - 696 WP_003910173.1 TetR/AcrR family transcriptional regulator -
JN147_RS03460 748320..749825 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JN147_RS03465 749906..750916 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN147_RS03470 751304..751687 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JN147_RS03475 751782..751937 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN147_RS03480 752013..752729 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN147_RS03485 753005..753313 - 309 WP_031652154.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN147_RS03490 753300..753545 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN147_RS03495 753655..754092 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN147_RS03500 754089..754343 - 255 WP_003911263.1 antitoxin VapB7 -
JN147_RS03505 754457..756825 + 2369 Protein_693 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T189109 WP_003403365.1 NZ_CP069066:c751687-751304 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T189109 NZ_CP090641:c2625199-2624861 [Burkholderia contaminans]
ATGGTTGACATACTGCAATCCATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGGCGTCTTCGACACCTGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACT
GGAAGTCCGCCGGCTCGCCGGTCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGA
ACGATCTGGGTCATCCTGCTCTGCGGCGGCGATAAATCGTCGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGC
GCATCTCGACATGGAGTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT189109 WP_003403368.1 NZ_CP069066:c751937-751782 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT189109 NZ_CP090641:c2624857-2624558 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References