Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 714197..714846 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN147_RS03285 Protein ID WP_003403236.1
Coordinates 714451..714846 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN147_RS03280 Protein ID WP_003403235.1
Coordinates 714197..714451 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS03255 709328..709411 + 84 Protein_646 galactose-1-phosphate uridylyltransferase -
JN147_RS03260 709430..710512 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN147_RS03265 710509..711594 + 1086 WP_003910166.1 galactokinase -
JN147_RS03270 711989..713146 + 1158 WP_003903091.1 hypothetical protein -
JN147_RS03275 713157..714104 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN147_RS03280 714197..714451 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN147_RS03285 714451..714846 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN147_RS03290 714940..715680 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN147_RS03295 715812..716072 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN147_RS03300 716069..716476 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN147_RS03305 716548..717699 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
JN147_RS03310 717792..719519 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T189107 WP_003403236.1 NZ_CP069066:714451-714846 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T189107 NZ_CP090641:c1560724-1560443 [Burkholderia contaminans]
ATGACCTTTGAGCTTGCCTTTCTCGAACCTGCTCTGAAAGAGTGGAAGAAGCTCGATCGCACCGTTCGCGATCAGTTCAA
ATCCCGGCTCGCCGAGCGGCTCGAGAATCCTCGAATACCGTCCGCGAAGCTGCAGGGTCATCCGGACCGCTACAAGATCA
AGCTGCGCAGCGTCGGCTATCGGCTCGTGTACGAAGTGCGCGATTCGGAAGTGCTCGTACTGGTCGTGGCGGTCGGTCGA
CGCGAGCGCGATGCTGTCTATCTTGCCGCGATGAAGCGTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT189107 WP_003403235.1 NZ_CP069066:714197-714451 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT189107 NZ_CP090641:c1560962-1560714 [Burkholderia contaminans]
ATGCCTCATACCATTCTGGCCAACGTTACGGCGAGCGTTTCGGAACTGAAGCGGAATCCGATGGGCACGGTCGCGGCAGG
AGAGGGTTTCCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTATTGCATCCCGGCGAAGACCTGGGAGGCGATGG
TCGAACGCCTTGAAGATATCGAAGACAACGCGTTGGCCGACAAGCGCGCCAAGGAGAAGGTCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References