Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 708574..709199 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN147_RS03250 Protein ID WP_003403218.1
Coordinates 708798..709199 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN147_RS03245 Protein ID WP_003403213.1
Coordinates 708574..708801 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS03220 703753..703974 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN147_RS03225 704116..704721 + 606 WP_003898526.1 hypothetical protein -
JN147_RS03230 704740..707307 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
JN147_RS03235 707391..708140 + 750 WP_003898528.1 hypothetical protein -
JN147_RS03240 708137..708379 + 243 WP_003403210.1 hypothetical protein -
JN147_RS03245 708574..708801 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN147_RS03250 708798..709199 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN147_RS03255 709328..709411 + 84 Protein_646 galactose-1-phosphate uridylyltransferase -
JN147_RS03260 709430..710512 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN147_RS03265 710509..711594 + 1086 WP_003910166.1 galactokinase -
JN147_RS03270 711989..713146 + 1158 WP_003903091.1 hypothetical protein -
JN147_RS03275 713157..714104 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T189106 WP_003403218.1 NZ_CP069066:708798-709199 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T189106 NZ_CP090641:c523757-522861 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCACCATGCGGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCAACTGCTCGCGAATGCCGATCTCGCAACGGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATTGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCACA
AGCGGGCCATGCCGGCTACGTGGAAGCACCGGCCGTCTATTCCGCACTGATCGACGCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT189106 WP_003403213.1 NZ_CP069066:708574-708801 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT189106 NZ_CP090641:c522864-522007 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACGACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGGACGCGCTTGCCCGCACATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGTTGAAGGAACTGCATGCGCTGTATCCGGAAGGCACGCTGAACCGCATGACGAACGCGAC
GCCGGAAACGGTCGATGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACACAGAGGATCGTGGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References