Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 701036..701679 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN147_RS03200 Protein ID WP_003403187.1
Coordinates 701278..701679 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN147_RS03195 Protein ID WP_003403184.1
Coordinates 701036..701281 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS03160 696318..696848 - 531 WP_031652151.1 two component system sensor kinase HK2 -
JN147_RS03165 696832..697527 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN147_RS03170 697650..697959 + 310 Protein_629 hypothetical protein -
JN147_RS03175 698031..698981 + 951 WP_003907436.1 DUF1259 domain-containing protein -
JN147_RS03180 699222..699806 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN147_RS03185 699808..700518 + 711 Protein_632 IS607 family element RNA-guided endonuclease TnpB -
JN147_RS03190 700521..700991 + 471 WP_003898523.1 hypothetical protein -
JN147_RS03195 701036..701281 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN147_RS03200 701278..701679 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN147_RS03205 701670..701849 + 180 Protein_636 hypothetical protein -
JN147_RS03210 702267..702464 - 198 WP_003403191.1 hypothetical protein -
JN147_RS03215 702544..703701 - 1158 WP_003403193.1 hypothetical protein -
JN147_RS03220 703753..703974 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN147_RS03225 704116..704721 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189105 WP_003403187.1 NZ_CP069066:701278-701679 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189105 NZ_CP090641:c241451-241035 [Burkholderia contaminans]
GTGTATTTGATTGACACGAATATCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGTGGCGTGCGGGCGTTTTTCAG
GCAGGCCGCGGCGGACGCAAGCCCGCTTTATCTTTCCGTCGTAACGGTTGCTGAACTTCGCCGCGGCGTCGATCTGATCC
GTCATCGTGGCGATCATCCCCAGGCGTCGGCGCTCGAGGCCTGGATGGCGACGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGACATCGAGATCAGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACCCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACGGTGGTCACGCGCAACGTCGAGGATTTCGCCCGCACCGGCGTCAAGCTGC
TGAACCCGTTCGACTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189105 WP_003403184.1 NZ_CP069066:701036-701281 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189105 NZ_CP090641:c241674-241438 [Burkholderia contaminans]
ATGGCAAATCTACTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCAAATGGCAGGAG
TGCCGAGGCCGAACATCGGGCCATCCTGGCCGATGCGCTCGGCCGGCCGAAGCGGAAGACATTTGCGCAAGTGCTGATGA
GCATGCCCGATGTTGGCGACGACGCGGATTTTCAACGTGTTCAGGATTCCGGCGAGGCCAGGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References