Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 441593..442604 Replicon chromosome
Accession NZ_CP069066
Organism Mycobacterium tuberculosis strain N1201

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag JN147_RS01935 Protein ID WP_003401859.1
Coordinates 441593..442186 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag JN147_RS01940 Protein ID WP_003401860.1
Coordinates 442215..442604 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN147_RS01915 437242..438624 + 1383 WP_003898415.1 magnesium transporter -
JN147_RS01920 438636..439670 - 1035 WP_003910109.1 class II fructose-bisphosphate aldolase -
JN147_RS01925 439766..440449 + 684 WP_003401857.1 VTT domain-containing protein -
JN147_RS01930 440438..441568 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
JN147_RS01935 441593..442186 - 594 WP_003401859.1 zeta toxin family protein Toxin
JN147_RS01940 442215..442604 - 390 WP_003401860.1 hypothetical protein Antitoxin
JN147_RS01945 442685..443896 - 1212 WP_003401861.1 VWA domain-containing protein -
JN147_RS01950 443902..444504 - 603 WP_003898417.1 SRPBCC family protein -
JN147_RS01955 444518..445414 - 897 WP_003401863.1 MoxR family ATPase -
JN147_RS01960 445411..446004 - 594 WP_003401864.1 NTP transferase domain-containing protein -
JN147_RS01965 446001..446756 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T189101 WP_003401859.1 NZ_CP069066:c442186-441593 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T189101 NZ_CP090640:1214137-1214538 [Burkholderia contaminans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGAATCAGCCGGAGCAGGTTGCGAGACGGTTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATCACGTACGCCGAGCTCGAGTACGGCGTCGCGGCGTGCGCGAGCC
CTGCGCGGGAGCGCGGCAATCTTGCCGCGCTGATCGACGACATTCCCGTTGCGCCGTTCGACGTCGCGGCCGCGCAAGCG
TATGGCCCGGTCCGCGAGGCAACCCGGGAGCGGAAGAAGGATCACCTCGACAAGCTGATCGCCGCGCATGCGGTGTCGCT
CGATGTCGTACTCGTGACCAACAACGAGCGGGATTTCGTGAGCTATCCGGGACTGCGGCTGGAGAACTGGCTGGACGATT
GA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT189101 WP_003401860.1 NZ_CP069066:c442604-442215 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT189101 NZ_CP090640:1213901-1214137 [Burkholderia contaminans]
ATGCATACGACGAGGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTTGCCTATGAACGCAGCGA
TATCGAACTGGAAATCGAGCGCATTGGTGACGAAATCCGCATTCGGCCGGCGCGGCGGCCGTTGACCCGCGTCCTTGAGA
AATTCGCTAAATTCGGGCCGGATTTCATGGCGGATGGGCGCGGTGACCACGAGCAGGCCGATCGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References