Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3151631..3152179 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JN148_RS14980 Protein ID WP_003414602.1
Coordinates 3151916..3152179 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JN148_RS14975 Protein ID WP_003414599.1
Coordinates 3151631..3151912 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS14950 3147254..3148111 - 858 WP_003910658.1 type I methionyl aminopeptidase -
JN148_RS14955 3148153..3148737 - 585 WP_003414585.1 DUF1707 domain-containing protein -
JN148_RS14960 3148895..3149089 + 195 WP_003414589.1 hypothetical protein -
JN148_RS14965 3149086..3149466 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JN148_RS14970 3149548..3151359 - 1812 WP_003414596.1 penicillin-binding protein -
JN148_RS14975 3151631..3151912 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JN148_RS14980 3151916..3152179 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN148_RS14985 3152552..3153406 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN148_RS14990 3153462..3154625 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN148_RS14995 3154642..3155856 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN148_RS15000 3155864..3157105 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T189090 WP_003414602.1 NZ_CP069065:3151916-3152179 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T189090 NZ_CP090636:1745319-1745738 [Burkholderia contaminans]
ATGATCCTTGTTGATACGAACGTGATGTCCGAGCCGCTGCGGCGTGAGCCGAGCACGGCCGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAAACGCTGTTTCTTGCTGCGATCAGTCTTGGCGAAATGCGCTTCGGCGTGGCGGCGCTCCCGGAAGGGC
GCAGGCGCGACTGGCTTCACCACAGCATCGAGCAACGCGTCGTGCCGCTGTTTCGCGGCAGGATTCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCATTCGAGCGCGTGCGCGTGCCTCGGGCAGTGCGATCGCGCCTGCCGATGTCTTTAT
TGCCGCGACGGCCGAGGCGAACGGATTGATCATTGCGACGCGCGACGTTGCGCCATTCGAGGCTGTCGGCCTGCGGGTGA
TTGATCCATGGGCGTCGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT189090 WP_003414599.1 NZ_CP069065:3151631-3151912 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT189090 NZ_CP090636:1745083-1745322 [Burkholderia contaminans]
ATGCCCGTGATTACCGTTCGAAATTTGCCCGATGAAGTGCACCGCGCGCTCCGAGTCCGTGCGGCGCAGCATGGGCGTAG
CACCGAAGCCGAGGTGCGTGACATCCTCGAGCAGGCCGTTCTGCCGGGCGGCCGGCTGAAGCTGGGAACGCTGCTGGCGG
AAATCGGACGGGAGGCGGGCGGCGTCGAATTCGACGTTCGGCGCGACAAGACGCTAACCGACCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References