Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3107804..3109578 | Replicon | chromosome |
| Accession | NZ_CP069065 | ||
| Organism | Mycobacterium tuberculosis strain N0091 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | JN148_RS14765 | Protein ID | WP_003414409.1 |
| Coordinates | 3107804..3108688 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | JN148_RS14770 | Protein ID | WP_003414414.1 |
| Coordinates | 3108691..3109578 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN148_RS14745 | 3103059..3103433 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| JN148_RS14750 | 3103430..3105868 | - | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| JN148_RS14755 | 3105865..3106653 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| JN148_RS14760 | 3106987..3107532 | - | 546 | WP_031667139.1 | DUF1802 family protein | - |
| JN148_RS14765 | 3107804..3108688 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JN148_RS14770 | 3108691..3109578 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JN148_RS14775 | 3109883..3110428 | - | 546 | WP_013988952.1 | DUF1802 family protein | - |
| JN148_RS14780 | 3110425..3110694 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| JN148_RS14785 | 3110715..3111107 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN148_RS14790 | 3111104..3111319 | - | 216 | WP_003910640.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| JN148_RS14795 | 3111366..3112115 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| JN148_RS14800 | 3112194..3113276 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T189088 WP_003414409.1 NZ_CP069065:c3108688-3107804 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T189088 NZ_CP090636:c1650620-1650354 [Burkholderia contaminans]
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTATGTCTACTGGCAGGGGCAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAACCGTTAAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGTCTGGTCTACGAGGCCGACGACTCGCAGATCAGCATC
GTGTCCTGCCGCTACCACTACGAATAG
ATGAGCGTACGCCGCGTGCTCTTTACTTCCGACGCGTGGGACGACTATGTCTACTGGCAGGGGCAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAACCGTTAAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGTCTGGTCTACGAGGCCGACGACTCGCAGATCAGCATC
GTGTCCTGCCGCTACCACTACGAATAG
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT189088 WP_003414414.1 NZ_CP069065:c3109578-3108691 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT189088 NZ_CP090636:c1650877-1650617 [Burkholderia contaminans]
ATGCGCACGATTCATTTTTCGGATGCCCGTGGCAATCTGAAGACCGTTATCGACCAGGTCGTCGATGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCGCCGAATGCCGTCATCATGTCGCAGGATTACTACGACAGCCTGATGGAGACGGTTCACT
TGCTGCGGTCTCCGGCCAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCGGCGGATGACGAATGA
ATGCGCACGATTCATTTTTCGGATGCCCGTGGCAATCTGAAGACCGTTATCGACCAGGTCGTCGATGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCGCCGAATGCCGTCATCATGTCGCAGGATTACTACGACAGCCTGATGGAGACGGTTCACT
TGCTGCGGTCTCCGGCCAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCGGCGGATGACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|