Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3043335..3044022 | Replicon | chromosome |
| Accession | NZ_CP069065 | ||
| Organism | Mycobacterium tuberculosis strain N0091 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TF65 |
| Locus tag | JN148_RS14420 | Protein ID | WP_003414064.1 |
| Coordinates | 3043627..3044022 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | JN148_RS14415 | Protein ID | WP_003414061.1 |
| Coordinates | 3043335..3043601 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN148_RS14385 | 3038974..3039876 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| JN148_RS14390 | 3039945..3040697 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| JN148_RS14400 | 3040941..3041216 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| JN148_RS14405 | 3041213..3042835 | - | 1623 | WP_013988948.1 | class I SAM-dependent DNA methyltransferase | - |
| JN148_RS14410 | 3042922..3043338 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
| JN148_RS14415 | 3043335..3043601 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| JN148_RS14420 | 3043627..3044022 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| JN148_RS14425 | 3044019..3044288 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| JN148_RS14430 | 3044298..3045392 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| JN148_RS14435 | 3045389..3045808 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| JN148_RS14440 | 3045807..3045881 | + | 75 | Protein_2850 | hypothetical protein | - |
| JN148_RS14445 | 3045882..3046361 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| JN148_RS14450 | 3046432..3047232 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| JN148_RS14455 | 3047388..3048125 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T189086 WP_003414064.1 NZ_CP069065:c3044022-3043627 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T189086 NZ_CP090636:c111159-110653 [Burkholderia contaminans]
ATGACGCTGCGCGCGCCCACCCCGATTACGCTCGAACATGCGCAGGCGGGCGCCCTGGACGCCTTCGATTCGGGTGAGCC
GAACCTGGACGATTGGCTCAAGCGGAGAGCCCTGCGTAACCACGTGAGCGGCGCGTCACGTACCTTTGTGGTGTGTGATG
ACCAGCGCGTCGTTGCCTACTACGCGCTAGCGTCGGGTGCGGTGGATGTCGCGGCCGCGCCCGGACGGTTTCGCCGCAAC
ATGCCGGACCCCGTACCGGTCGTCGTGTTGGCCAGGCTCGCGGTAGACCGGGCCTGGCAGGGCCGCGGACTGGGCCGCGG
GCTGTTGCGTGACGCCGGGCTACGGGTCATGCAGGCGGCGGACACCATCGGGATTCGCGGGCTGCTCGCACATGCACTGT
CGGCCGACGCGCAGCGCTTCTATCTGCAGGTCGGATTCGAGCCGTCGCCGCTTGACCCTATGACAGTCATGATCACACTG
ACCGATTTGCGCGCGTCGTTGACGTGA
ATGACGCTGCGCGCGCCCACCCCGATTACGCTCGAACATGCGCAGGCGGGCGCCCTGGACGCCTTCGATTCGGGTGAGCC
GAACCTGGACGATTGGCTCAAGCGGAGAGCCCTGCGTAACCACGTGAGCGGCGCGTCACGTACCTTTGTGGTGTGTGATG
ACCAGCGCGTCGTTGCCTACTACGCGCTAGCGTCGGGTGCGGTGGATGTCGCGGCCGCGCCCGGACGGTTTCGCCGCAAC
ATGCCGGACCCCGTACCGGTCGTCGTGTTGGCCAGGCTCGCGGTAGACCGGGCCTGGCAGGGCCGCGGACTGGGCCGCGG
GCTGTTGCGTGACGCCGGGCTACGGGTCATGCAGGCGGCGGACACCATCGGGATTCGCGGGCTGCTCGCACATGCACTGT
CGGCCGACGCGCAGCGCTTCTATCTGCAGGTCGGATTCGAGCCGTCGCCGCTTGACCCTATGACAGTCATGATCACACTG
ACCGATTTGCGCGCGTCGTTGACGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT189086 WP_003414061.1 NZ_CP069065:c3043601-3043335 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT189086 NZ_CP090636:c111461-111156 [Burkholderia contaminans]
ATGTCCGCTACCCATAGCCCCCCGACCAAGCGCGACACCCTGAACTTGCGCGTGCAGCCTGATGAACGCAACCTGATCGA
TCGCGCGGCCGCCGCACGCGGGCAGAACCGCACCGACTTCATCCTGTCCGCCGCCCGCGCGGCCGCTGAGGAAACCCTGC
TCGAGGCGACGCTGGTGCGCGCCAGTCCCGACGCGTATGCCGCGTTCGTCGCGCGGCTCGACGCGCCACCGGCGCCGAAT
CCCCAGTTGCGGCGCACGATGCGGACGCCCGCGCCGTGGGACGGCTCGGCCGACCCCGTCGCATGA
ATGTCCGCTACCCATAGCCCCCCGACCAAGCGCGACACCCTGAACTTGCGCGTGCAGCCTGATGAACGCAACCTGATCGA
TCGCGCGGCCGCCGCACGCGGGCAGAACCGCACCGACTTCATCCTGTCCGCCGCCCGCGCGGCCGCTGAGGAAACCCTGC
TCGAGGCGACGCTGGTGCGCGCCAGTCCCGACGCGTATGCCGCGTTCGTCGCGCGGCTCGACGCGCCACCGGCGCCGAAT
CCCCAGTTGCGGCGCACGATGCGGACGCCCGCGCCGTGGGACGGCTCGGCCGACCCCGTCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|