Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2852343..2852974 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag JN148_RS13380 Protein ID WP_003413174.1
Coordinates 2852597..2852974 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag JN148_RS13375 Protein ID WP_003413167.1
Coordinates 2852343..2852600 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T189082 WP_003413174.1 NZ_CP069065:2852597-2852974 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T189082 NZ_CP090635:1401076-1401237 [Burkholderia contaminans]
GTGACCACGCTCTACATGCTCGATACGAGCATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCCCGGTT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTCTCGGCAATTACCTATGCCGAAATGCGATTCGGCGCGGCCGGCT
AG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT189082 WP_003413167.1 NZ_CP069065:2852343-2852600 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT189082 NZ_CP090635:1400813-1401079 [Burkholderia contaminans]
ATGCGCACCGTTTCCATTTTCAAGAATGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
CGAACTCGAGATTCGCCGCGAGGGCGACACGCTGCTGCTGCGGCCGGTGCGGCCCACATGGCTCTCGTTCGCGAGCGAAC
CGCCGGCCGACGCCGACTTCCTCGCCGAACGCCCGGCCGTCATCGAGCCCGGCCGCTTCGACCTGTCCGACGGTGGCGGC
GCCGCACCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References