189078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2387815..2388344 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN148_RS11190 Protein ID WP_003411124.1
Coordinates 2387815..2388132 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN148_RS11195 Protein ID WP_003411127.1
Coordinates 2388129..2388344 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS11160 2382836..2383912 + 1077 WP_003411110.1 hypothetical protein -
JN148_RS11165 2383909..2384190 + 282 WP_003411112.1 DUF5703 family protein -
JN148_RS11170 2384226..2385299 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN148_RS11175 2385304..2385834 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN148_RS11180 2385882..2387228 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN148_RS11190 2387815..2388132 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN148_RS11195 2388129..2388344 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN148_RS11200 2388599..2389657 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN148_RS11205 2389787..2390143 - 357 WP_003411130.1 hypothetical protein -
JN148_RS11210 2390238..2391020 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN148_RS11215 2391288..2391578 - 291 WP_003900476.1 YggT family protein -
JN148_RS11220 2391740..2392396 - 657 WP_003411133.1 cell division protein SepF -
JN148_RS11225 2392462..2393238 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189078 WP_003411124.1 NZ_CP069065:c2388132-2387815 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189078 NZ_CP090633:1759617-1760033 [Burkholderia contaminans]
GTGTATTTGATTGACACGAATATCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGTGGCGTGCGGGCGTTTTTCAG
GCAGGCCGCGGCGGACGCAAGCCCGCTTTACCTTTCTGTCGTAACGGTTGCTGAACTTCGCCGCGGCGTCGATCTGATCC
GTCATCGCGGCGATCATCCCCAGGCGTCGGCGCTCGAGGCCTGGATGGCGACCATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGACATCGAGATCAGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACTGTGGTCACGCGCAACGTCGCGGATTTCGCCCGCACCGGTGTCCGGCTGC
TGAACCCGTTCGACTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189078 WP_003411127.1 NZ_CP069065:c2388344-2388129 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189078 NZ_CP090633:1759394-1759630 [Burkholderia contaminans]
ATGGCAAATCTACTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCAAATGGCAGGAG
TGCCGAGGCCGAACATCGGGCCATCCTGGCCGATGCGCTCGGCCGGCCGAAGCGAAAGACATTTGCGCAAGTGCTGATGA
GCATGCCCGATGTTGGTGACGACGCGGATTTTCAACGTGTTCAGGATTCCGGCGAGGCCAGGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References