Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2351008..2351703 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN148_RS10985 Protein ID WP_003410811.1
Coordinates 2351008..2351442 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN148_RS10990 Protein ID WP_003410814.1
Coordinates 2351449..2351703 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS10975 2347162..2350203 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN148_RS10980 2350196..2351029 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN148_RS10985 2351008..2351442 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN148_RS10990 2351449..2351703 - 255 WP_003410814.1 antitoxin Antitoxin
JN148_RS10995 2351719..2351976 - 258 WP_003410816.1 hypothetical protein -
JN148_RS11000 2352923..2353219 + 297 WP_003410820.1 PE family protein -
JN148_RS11005 2353275..2354006 + 732 WP_003900467.1 PPE family protein -
JN148_RS11010 2354546..2355292 - 747 WP_003901330.1 proteasome subunit alpha -
JN148_RS11015 2355289..2356164 - 876 WP_003411023.1 proteasome subunit beta -
JN148_RS11020 2356161..2356355 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189077 WP_003410811.1 NZ_CP069065:c2351442-2351008 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189077 NZ_CP090633:1487511-1488407 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACGGCGTTG
CGCGGCCGGCGCTGCGGGCACGATCGGATATCGTGAGGCCGGCGCGCAGCATGCGGGTCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGTCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGCCATTCGCTCGGCGCGATCATCGCGGGTGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTATCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTGGCGAACGCCGATCTCGCAACGGATCTCGCGGGCTTTCGCGGCCGGACGGCCGTGGCCGTCGGC
GCGAATGACGCGATCACGCCGCCCGCCGCGTGCGAGCGCGTCGCCGCGGCCGCGCATGTCGGGCTGCAGGTGATTCCGCA
GGCAGGCCATGCCGGCTACGTGGAAGCACCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGACTGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189077 WP_003410814.1 NZ_CP069065:c2351703-2351449 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189077 NZ_CP090633:1488404-1489261 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACAACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCTGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAATTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGTGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAACGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACGCAGAAGATCGTGGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTACAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References