Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2200488..2201032 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN148_RS10275 Protein ID WP_003409896.1
Coordinates 2200488..2200784 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN148_RS10280 Protein ID WP_003409899.1
Coordinates 2200781..2201032 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS10220 2195521..2195871 - 351 WP_003910480.1 hypothetical protein -
JN148_RS10225 2195882..2196784 - 903 WP_003409874.1 hypothetical protein -
JN148_RS10230 2196805..2196996 - 192 WP_003409876.1 hypothetical protein -
JN148_RS10235 2196997..2197293 - 297 WP_003409877.1 hypothetical protein -
JN148_RS10240 2197533..2197748 + 216 WP_003409878.1 antitoxin -
JN148_RS10245 2197745..2198056 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN148_RS10250 2198030..2198551 - 522 WP_003904745.1 hypothetical protein -
JN148_RS10255 2198526..2198903 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN148_RS10260 2198945..2199394 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN148_RS10265 2199391..2199936 + 546 WP_003409891.1 SecB-like chaperone -
JN148_RS10270 2199825..2200439 - 615 WP_003901296.1 hypothetical protein -
JN148_RS10275 2200488..2200784 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN148_RS10280 2200781..2201032 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN148_RS10285 2201019..2201513 + 495 WP_003899099.1 hypothetical protein -
JN148_RS10290 2201673..2202080 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN148_RS10295 2202084..2202356 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN148_RS10300 2202389..2203609 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN148_RS10305 2204508..2204813 + 306 Protein_2037 ABC transporter permease -
JN148_RS10310 2204809..2204889 + 81 Protein_2038 hypothetical protein -
JN148_RS10315 2204997..2205845 + 849 WP_003910485.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T189070 WP_003409896.1 NZ_CP069065:c2200784-2200488 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T189070 NZ_CP090629:c4879331-4879047 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT189070 WP_003409899.1 NZ_CP069065:c2201032-2200781 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT189070 NZ_CP090629:c4879563-4879321 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References