Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 753302..753990 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN148_RS03500 Protein ID WP_003403386.1
Coordinates 753302..753739 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag JN148_RS03505 Protein ID WP_003911263.1
Coordinates 753736..753990 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS03470 749553..750563 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN148_RS03475 750951..751334 - 384 WP_003403365.1 ribonuclease VapC6 -
JN148_RS03480 751429..751584 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JN148_RS03485 751660..752376 - 717 WP_013988760.1 CPBP family intramembrane metalloprotease -
JN148_RS03490 752652..752960 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN148_RS03495 752947..753192 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN148_RS03500 753302..753739 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN148_RS03505 753736..753990 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
JN148_RS03510 754104..756467 + 2364 WP_003403397.1 arylsulfatase AtsD -
JN148_RS03515 756530..756856 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN148_RS03520 756768..757106 + 339 WP_003403405.1 PIN domain-containing protein -
JN148_RS03525 757103..757276 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T189054 WP_003403386.1 NZ_CP069065:c753739-753302 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T189054 NZ_CP090626:1994224-1994326 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT189054 WP_003911263.1 NZ_CP069065:c753990-753736 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT189054 NZ_CP090626:c1994333-1994188 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References