Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 750951..751584 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JN148_RS03475 Protein ID WP_003403365.1
Coordinates 750951..751334 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JN148_RS03480 Protein ID WP_003403368.1
Coordinates 751429..751584 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS03450 746243..746779 + 537 WP_003403341.1 50S ribosomal protein L10 -
JN148_RS03455 746816..747208 + 393 WP_013988758.1 50S ribosomal protein L7/L12 -
JN148_RS03460 747201..747896 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JN148_RS03465 747967..749472 + 1506 WP_013988759.1 carotenoid cleavage oxygenase -
JN148_RS03470 749553..750563 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN148_RS03475 750951..751334 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JN148_RS03480 751429..751584 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN148_RS03485 751660..752376 - 717 WP_013988760.1 CPBP family intramembrane metalloprotease -
JN148_RS03490 752652..752960 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN148_RS03495 752947..753192 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN148_RS03500 753302..753739 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JN148_RS03505 753736..753990 - 255 WP_003911263.1 antitoxin VapB7 -
JN148_RS03510 754104..756467 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T189051 WP_003403365.1 NZ_CP069065:c751334-750951 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T189051 NZ_CP090626:352720-353067 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT189051 WP_003403368.1 NZ_CP069065:c751584-751429 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT189051 NZ_CP090626:353067-353366 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References