Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 675151..675770 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag JN148_RS03070 Protein ID WP_003403047.1
Coordinates 675363..675770 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag JN148_RS03065 Protein ID WP_003403039.1
Coordinates 675151..675366 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS03055 673679..674437 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
JN148_RS03060 674566..675057 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
JN148_RS03065 675151..675366 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
JN148_RS03070 675363..675770 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
JN148_RS03075 675830..676516 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
JN148_RS03080 676670..679303 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T189044 WP_003403047.1 NZ_CP069065:675363-675770 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T189044 NZ_CP090623:4165638-4165856 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT189044 WP_003403039.1 NZ_CP069065:675151-675366 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT189044 NZ_CP090623:4165237-4165611 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References