Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 361179..361822 Replicon chromosome
Accession NZ_CP069065
Organism Mycobacterium tuberculosis strain N0091

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag JN148_RS01590 Protein ID WP_003401566.1
Coordinates 361397..361822 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JN148_RS01585 Protein ID WP_003401563.1
Coordinates 361179..361400 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN148_RS01560 356253..357056 - 804 WP_003401540.1 Stf0 family sulphotransferase -
JN148_RS01565 357066..358463 - 1398 WP_013988728.1 sulfatase -
JN148_RS01570 358642..360462 + 1821 WP_003401546.1 PE family protein -
JN148_RS01575 360605..360832 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JN148_RS01580 360829..361131 + 303 WP_003401560.1 toxin-antitoxin system toxin -
JN148_RS01585 361179..361400 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JN148_RS01590 361397..361822 + 426 WP_003401566.1 PIN domain nuclease Toxin
JN148_RS01595 361958..362590 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JN148_RS01600 362587..363495 + 909 WP_003900117.1 protochlorophyllide reductase -
JN148_RS01605 363503..363778 - 276 WP_244693123.1 hypothetical protein -
JN148_RS01610 363800..364093 - 294 WP_244693222.1 hypothetical protein -
JN148_RS01615 364086..364136 - 51 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T189042 WP_003401566.1 NZ_CP069065:361397-361822 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T189042 NZ_CP090623:1995528-1995630 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT189042 WP_003401563.1 NZ_CP069065:361179-361400 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT189042 NZ_CP090623:c1995637-1995492 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References