Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3691243..3691917 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JN149_RS17370 Protein ID WP_003417282.1
Coordinates 3691243..3691671 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN149_RS17375 Protein ID WP_003417286.1
Coordinates 3691675..3691917 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS17345 3687065..3687466 - 402 WP_003417264.1 cytidine deaminase -
JN149_RS17350 3687703..3688041 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
JN149_RS17355 3688038..3688472 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN149_RS17360 3688601..3690373 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN149_RS17365 3690373..3691164 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN149_RS17370 3691243..3691671 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS17375 3691675..3691917 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
JN149_RS17380 3692039..3692653 - 615 WP_244735045.1 class I SAM-dependent methyltransferase -
JN149_RS17385 3692650..3693228 - 579 Protein_3437 molybdenum cofactor biosynthesis protein MoaE -
JN149_RS17395 3694581..3694673 - 93 Protein_3439 molybdopterin converting factor subunit 1 -
JN149_RS17400 3694674..3695207 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN149_RS17405 3695204..3695578 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JN149_RS17410 3695675..3696679 - 1005 WP_234787058.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189035 WP_003417282.1 NZ_CP069064:c3691671-3691243 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189035 NZ_CP090622:c4756623-4756339 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189035 WP_003417286.1 NZ_CP069064:c3691917-3691675 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189035 NZ_CP090622:c4756855-4756613 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References