Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3118919..3119523 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag JN149_RS14775 Protein ID WP_003414492.1
Coordinates 3118919..3119311 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN149_RS14780 Protein ID WP_003910640.1
Coordinates 3119308..3119523 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS14745 3114069..3114857 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
JN149_RS14750 3115191..3115736 - 546 WP_031652371.1 DUF1802 family protein -
JN149_RS14755 3116008..3116892 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
JN149_RS14760 3116895..3117782 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
JN149_RS14765 3118087..3118632 - 546 WP_003899500.1 DUF1802 family protein -
JN149_RS14770 3118629..3118898 - 270 WP_003414489.1 DUF2277 family protein -
JN149_RS14775 3118919..3119311 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS14780 3119308..3119523 - 216 WP_003910640.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JN149_RS14785 3119570..3120319 + 750 WP_003414497.1 enoyl-CoA hydratase -
JN149_RS14790 3120398..3121480 - 1083 WP_003414499.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
JN149_RS14795 3121473..3122783 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
JN149_RS14800 3122786..3123613 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
JN149_RS14805 3123610..3124521 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T189031 WP_003414492.1 NZ_CP069064:c3119311-3118919 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T189031 NZ_CP090622:1959541-1959643 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7495.55 Da        Isoelectric Point: 4.9732

>AT189031 WP_003910640.1 NZ_CP069064:c3119523-3119308 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVAWNVS

Download         Length: 216 bp

>AT189031 NZ_CP090622:c1959650-1959505 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure

References