Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2799385..2800037 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag JN149_RS13075 Protein ID WP_003412752.1
Coordinates 2799612..2800037 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag JN149_RS13070 Protein ID WP_003412749.1
Coordinates 2799385..2799606 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS13055 2797625..2797831 - 207 WP_003899347.1 hypothetical protein -
JN149_RS13060 2797967..2798590 + 624 WP_003900858.1 TIGR00725 family protein -
JN149_RS13065 2798580..2799332 + 753 WP_003901416.1 hypothetical protein -
JN149_RS13070 2799385..2799606 + 222 WP_003412749.1 antitoxin Antitoxin
JN149_RS13075 2799612..2800037 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS13080 2800060..2801241 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
JN149_RS13085 2801238..2802284 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
JN149_RS13090 2802295..2803398 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
JN149_RS13095 2803657..2804478 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
JN149_RS13100 2804475..2805032 - 558 WP_244735033.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T189021 WP_003412752.1 NZ_CP069064:2799612-2800037 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T189021 NZ_CP090615:394522-395055 [Vibrio pelagius]
GTGAGTTGGGGTAAAGAGTTCGTAGAGCTTAGTAAATCAAAGCATGATCGCAACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTTCTCAAC
CACTGTTAAATCAAAAATTCGCTATTTGTGCATTTTATAGTGTTGCACCGAGTTCAATCAGCCGAGAAATATTACCAGCA
CAACAAGCAAAGAAACTTCCTAGGTATCCAATCCCTGTTTTTGTGTTGGCTCAGTTAGCTGTCCACAAAGAGTTTCATGG
CTCTGGGCTCGGAAAGGTTAGTCTAATTCGAGCACTGAAGTACTTATGGGAAGTGAATCGCTATATGAGGGCGTACGCAA
TTGTTGTGGACTGTCTGACAGATTCCGCTCAAGCGTTCTATGCGAAGTTCGACTTTGAAGTGCTGTGCGAACATAATGGG
CGTATTCGTATGTTTTTACCAATGAAAACGGTAGAACAGCTTTTTAATCAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT189021 WP_003412749.1 NZ_CP069064:2799385-2799606 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT189021 NZ_CP090615:394256-394525 [Vibrio pelagius]
ATGGCAACGGCACGTTTAGATATTCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAAGCATCGGCTTTACTTGGTTT
AAAAAGTCTCACTGAATATGTAGTGAGACTAATGGACGAAGATGCGACTCATGTTATTGAGGAACATGAAAGTATTATGG
TTAAAGACAGTGTCTTTGACGAGTTTATGGCTGCGTGCAATAAAGCAAAAGCACCGAATCAAGCTTTGATTGAAGCTGCC
AAATTTACAGATGAGAGTGGTATTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References