Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2396114..2396643 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN149_RS11180 Protein ID WP_003411124.1
Coordinates 2396114..2396431 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN149_RS11185 Protein ID WP_003411127.1
Coordinates 2396428..2396643 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS11150 2391135..2392211 + 1077 WP_003411110.1 hypothetical protein -
JN149_RS11155 2392208..2392489 + 282 WP_003411112.1 DUF5703 family protein -
JN149_RS11160 2392525..2393598 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN149_RS11165 2393603..2394133 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN149_RS11170 2394181..2395527 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN149_RS11180 2396114..2396431 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN149_RS11185 2396428..2396643 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN149_RS11190 2396898..2397956 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
JN149_RS11195 2398086..2398442 - 357 WP_003411130.1 hypothetical protein -
JN149_RS11200 2398537..2399319 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN149_RS11205 2399587..2399877 - 291 WP_003900476.1 YggT family protein -
JN149_RS11210 2400039..2400695 - 657 WP_003411133.1 cell division protein SepF -
JN149_RS11215 2400761..2401537 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189020 WP_003411124.1 NZ_CP069064:c2396431-2396114 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189020 NZ_CP090615:c393614-393324 [Vibrio pelagius]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
AAAAAAGCTAGTCGAGCGCTTGGATAACCCACATGTTCCGGCTTCAAAACTATCTGGATCTGACAACATGTATAAAATTA
AGCTGCGTCAATCAGGCTATCGCATTGTCTACAAAGTTGAAGATGATGTCATTGTTGTAACCGTACTAGCAGTAGGAAAA
CGCGAACGTAGCGGTGTTTACCGTAACGCTATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189020 WP_003411127.1 NZ_CP069064:c2396643-2396428 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189020 NZ_CP090615:c393852-393604 [Vibrio pelagius]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGTATTACTGAGTTGAAAGCCAACCCAATGAAAGTCGCATCTAGTGC
TTACGGTGAACCTGTTGCTGTACTAAACCGAAATGAGCCAGTATTTTATTGCGTGCCTGCCAAAGCCTACGAAATGATGA
TGGACAGGCTCGAAGATCTTGAACTACTCGCTATCGCTAATGAACGAGAGTCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References