Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2359310..2360005 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JN149_RS10975 Protein ID WP_003410811.1
Coordinates 2359310..2359744 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JN149_RS10980 Protein ID WP_003410814.1
Coordinates 2359751..2360005 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS10965 2355464..2358505 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JN149_RS10970 2358498..2359331 + 834 WP_003899172.1 SWIM zinc finger family protein -
JN149_RS10975 2359310..2359744 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS10980 2359751..2360005 - 255 WP_003410814.1 antitoxin Antitoxin
JN149_RS10985 2360021..2360278 - 258 WP_003410816.1 hypothetical protein -
JN149_RS10990 2361225..2361521 + 297 WP_003410820.1 PE family protein -
JN149_RS10995 2361577..2362308 + 732 WP_003900467.1 PPE family protein -
JN149_RS11000 2362848..2363594 - 747 WP_003901330.1 proteasome subunit alpha -
JN149_RS11005 2363591..2364466 - 876 WP_003411023.1 proteasome subunit beta -
JN149_RS11010 2364463..2364657 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T189019 WP_003410811.1 NZ_CP069064:c2359744-2359310 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T189019 NZ_CP090614:2824722-2825024 [Vibrio pelagius]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTTTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTGTTCTGTTCGTTATGCGTGTAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT189019 WP_003410814.1 NZ_CP069064:c2360005-2359751 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT189019 NZ_CP090614:2824477-2824734 [Vibrio pelagius]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTTGCCGATCTCCATGATACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGATTACGAATCTATGAAAAATCGTTTAGCTA
TTCTAGAGGGTATTGCACGAGGTGAGCGTGCGCTAGCTGATGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCGAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References