Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2217718..2218406 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN149_RS10330 Protein ID WP_003409958.1
Coordinates 2217718..2218137 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN149_RS10335 Protein ID WP_003409968.1
Coordinates 2218146..2218406 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS10300 2212724..2213029 + 306 Protein_2036 ABC transporter permease -
JN149_RS10305 2213025..2213105 + 81 Protein_2037 hypothetical protein -
JN149_RS10310 2213213..2214061 + 849 WP_003910485.1 class I SAM-dependent methyltransferase -
JN149_RS10315 2214024..2215469 - 1446 WP_003409946.1 APC family permease -
JN149_RS10320 2215648..2216334 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN149_RS10325 2216525..2217493 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN149_RS10330 2217718..2218137 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS10335 2218146..2218406 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN149_RS10340 2218549..2220225 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN149_RS10345 2220213..2220866 - 654 WP_003409976.1 cutinase Cfp21 -
JN149_RS10350 2220981..2221211 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN149_RS10355 2221296..2222207 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN149_RS10360 2222316..2222915 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T189013 WP_003409958.1 NZ_CP069064:c2218137-2217718 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T189013 NZ_CP090611:3097768-3097986 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT189013 WP_003409968.1 NZ_CP069064:c2218406-2218146 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT189013 NZ_CP090611:3097368-3097742 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References