Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2208704..2209248 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JN149_RS10270 Protein ID WP_003409896.1
Coordinates 2208704..2209000 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JN149_RS10275 Protein ID WP_003409899.1
Coordinates 2208997..2209248 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS10215 2203737..2204087 - 351 WP_003910480.1 hypothetical protein -
JN149_RS10220 2204098..2205000 - 903 WP_003409874.1 hypothetical protein -
JN149_RS10225 2205021..2205212 - 192 WP_003409876.1 hypothetical protein -
JN149_RS10230 2205213..2205509 - 297 WP_003409877.1 hypothetical protein -
JN149_RS10235 2205749..2205964 + 216 WP_003409878.1 antitoxin -
JN149_RS10240 2205961..2206272 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN149_RS10245 2206246..2206767 - 522 WP_003904745.1 hypothetical protein -
JN149_RS10250 2206742..2207119 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JN149_RS10255 2207161..2207610 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
JN149_RS10260 2207607..2208152 + 546 WP_003409891.1 SecB-like chaperone -
JN149_RS10265 2208041..2208655 - 615 WP_003901296.1 hypothetical protein -
JN149_RS10270 2208704..2209000 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN149_RS10275 2208997..2209248 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JN149_RS10280 2209235..2209729 + 495 WP_244735024.1 hypothetical protein -
JN149_RS10285 2209889..2210296 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN149_RS10290 2210300..2210572 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN149_RS10295 2210605..2211825 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
JN149_RS10300 2212724..2213029 + 306 Protein_2036 ABC transporter permease -
JN149_RS10305 2213025..2213105 + 81 Protein_2037 hypothetical protein -
JN149_RS10310 2213213..2214061 + 849 WP_003910485.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T189012 WP_003409896.1 NZ_CP069064:c2209000-2208704 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T189012 NZ_CP090611:2401396-2401890 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT189012 WP_003409899.1 NZ_CP069064:c2209248-2208997 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT189012 NZ_CP090611:2401106-2401399 [Escherichia coli]
ATGGCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References