Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1227849..1228480 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag JN149_RS05890 Protein ID WP_003405820.1
Coordinates 1227849..1228160 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag JN149_RS05895 Protein ID WP_003405836.1
Coordinates 1228160..1228480 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS05870 1223331..1224755 - 1425 WP_003405805.1 class II fumarate hydratase -
JN149_RS05875 1224786..1225874 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
JN149_RS05880 1225930..1226574 + 645 WP_003915494.1 DUF4245 domain-containing protein -
JN149_RS05885 1226581..1227737 - 1157 Protein_1161 AI-2E family transporter -
JN149_RS05890 1227849..1228160 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
JN149_RS05895 1228160..1228480 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
JN149_RS05900 1228490..1230026 + 1537 Protein_1164 carboxylesterase/lipase family protein -
JN149_RS05905 1230033..1231145 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
JN149_RS05910 1231155..1231412 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
JN149_RS05915 1231402..1232649 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
JN149_RS05920 1232646..1233284 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T189000 WP_003405820.1 NZ_CP069064:c1228160-1227849 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T189000 NZ_CP090611:217188-217295 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT189000 WP_003405836.1 NZ_CP069064:c1228480-1228160 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT189000 NZ_CP090611:c217139-217076 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References