Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1020463..1021436 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag JN149_RS04870 Protein ID WP_003404756.1
Coordinates 1020936..1021436 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag JN149_RS04865 Protein ID WP_003404754.1
Coordinates 1020463..1020939 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS04845 1016310..1017581 - 1272 WP_003404747.1 PPE family protein -
JN149_RS04850 1017596..1017895 - 300 WP_003404748.1 PE family protein -
JN149_RS04855 1018339..1020120 + 1782 WP_003404749.1 BCCT family transporter -
JN149_RS04860 1020120..1020374 + 255 WP_003898646.1 hypothetical protein -
JN149_RS04865 1020463..1020939 + 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
JN149_RS04870 1020936..1021436 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
JN149_RS04880 1021749..1023068 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
JN149_RS04885 1023356..1023937 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
JN149_RS04890 1023937..1025589 + 1653 WP_003404761.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T188998 WP_003404756.1 NZ_CP069064:1020936-1021436 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T188998 NZ_CP090610:1183182-1183565 [Burkholderia cepacia]
ATGAGTGTCTTGGTCGACACGTCCGTGTGGGTCGAGCATTTCCGGCGGCCACTCCCGGCACTTATCCAACTTCTGCGCGT
CGATAGCATCCTTACACATCCGCTGGTGATACTTGAGCTCACGTGCGGGACACCACCCGAACCGCGGGCACGAACGCTGG
GAGATCTCGCGTTATTGCGCCAAACGCGCCTCGCGACGCCAGGCGAAGTAGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTGCCGTGGATTGCACGCTGCTTGCATCGGTGCTGTTGACCCCGAGCACCCGGCTCTGGACGCGTGA
TCGGCGGCTCGCGCAACTGGCAGAGCGATTCGGGGCCCAATACGTACCGCCTGACCTGCATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT188998 WP_003404754.1 NZ_CP069064:1020463-1020939 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT188998 NZ_CP090610:1182979-1183185 [Burkholderia cepacia]
ATGCGTACCACCGTCACCGTCGACGACACTCTCTATGCGCGCGCACTCGAACTCGCCGAACCGGGCATGCCGCCGGCCGA
CCTGTTCCGGGCGGCACTTGAAACCTTCGTGCGTGTTCAGGCCGGTCAACGCCTAGCCGCCCTGGGCGGTCGCGCGCCCG
ACATGGCAGATGTCCCGCGCCGCGCCGCTGAGGCAACCGCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References