Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 752557..753245 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JN149_RS03500 Protein ID WP_003403386.1
Coordinates 752557..752994 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag JN149_RS03505 Protein ID WP_003911263.1
Coordinates 752991..753245 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS03470 748808..749818 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JN149_RS03475 750206..750589 - 384 WP_003403365.1 ribonuclease VapC6 -
JN149_RS03480 750684..750839 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JN149_RS03485 750915..751631 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
JN149_RS03490 751907..752215 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JN149_RS03495 752202..752447 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JN149_RS03500 752557..752994 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS03505 752991..753245 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
JN149_RS03510 753359..755722 + 2364 WP_003403397.1 arylsulfatase AtsD -
JN149_RS03515 755785..756111 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN149_RS03520 756023..756361 + 339 WP_003403405.1 PIN domain-containing protein -
JN149_RS03525 756358..756531 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T188996 WP_003403386.1 NZ_CP069064:c752994-752557 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T188996 NZ_CP090609:3081789-3082208 [Burkholderia cepacia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGCTCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCGTTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACACGCTCGTGCCGCAGGTGTCGCAATTGCACCTTCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGACGTCACGCCGTTCGAGGCAATGGGAATTCGCGTAA
TCGACCCGTGGGCGCGCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT188996 WP_003911263.1 NZ_CP069064:c753245-752991 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT188996 NZ_CP090609:3081553-3081792 [Burkholderia cepacia]
ATGCCGGTGATCACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCAGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGACCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References