Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 707476..708101 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN149_RS03255 Protein ID WP_003403218.1
Coordinates 707700..708101 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN149_RS03250 Protein ID WP_003403213.1
Coordinates 707476..707703 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS03225 702655..702876 - 222 WP_031666828.1 DUF4926 domain-containing protein -
JN149_RS03230 703018..703623 + 606 WP_003898526.1 hypothetical protein -
JN149_RS03235 703642..706209 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
JN149_RS03240 706293..707042 + 750 WP_003898528.1 hypothetical protein -
JN149_RS03245 707039..707281 + 243 WP_003403210.1 hypothetical protein -
JN149_RS03250 707476..707703 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN149_RS03255 707700..708101 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN149_RS03260 708230..708313 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
JN149_RS03265 708332..709414 + 1083 WP_244735094.1 galactose-1-phosphate uridylyltransferase -
JN149_RS03270 709411..710496 + 1086 WP_003910166.1 galactokinase -
JN149_RS03275 710891..712048 + 1158 WP_003903091.1 hypothetical protein -
JN149_RS03280 712059..713006 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T188990 WP_003403218.1 NZ_CP069064:707700-708101 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T188990 NZ_CP090609:c289067-288771 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGACCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCAAGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT188990 WP_003403213.1 NZ_CP069064:707476-707703 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT188990 NZ_CP090609:c288768-288367 [Burkholderia cepacia]
ATGAAATGTCCTGCATGCGGTGCCGCGAAGCTCGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCTGTCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAAGCGACCCGTTTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGACGGTACGCAAGAAG
CTGAAGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAATGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCCGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References