Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 699938..700581 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN149_RS03205 Protein ID WP_003403187.1
Coordinates 700180..700581 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN149_RS03200 Protein ID WP_003403184.1
Coordinates 699938..700183 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS03165 695220..695750 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN149_RS03170 695734..696429 - 696 WP_003918099.1 two-component system response regulator TcrA -
JN149_RS03175 696552..696861 + 310 Protein_630 hypothetical protein -
JN149_RS03180 696933..697883 + 951 WP_031666827.1 DUF1259 domain-containing protein -
JN149_RS03185 698124..698708 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN149_RS03190 698710..699420 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -
JN149_RS03195 699423..699893 + 471 WP_003898523.1 hypothetical protein -
JN149_RS03200 699938..700183 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN149_RS03205 700180..700581 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN149_RS03210 700572..700751 + 180 Protein_637 hypothetical protein -
JN149_RS03215 701169..701366 - 198 WP_003403191.1 hypothetical protein -
JN149_RS03220 701446..702603 - 1158 WP_003403193.1 hypothetical protein -
JN149_RS03225 702655..702876 - 222 WP_031666828.1 DUF4926 domain-containing protein -
JN149_RS03230 703018..703623 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T188989 WP_003403187.1 NZ_CP069064:700180-700581 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T188989 NZ_CP090608:1971335-1971751 [Burkholderia cepacia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCGACGGCCGCGATTCGTGCCGATCTCGCCGCGCGCGGCACGCCGATCGGTGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCCGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAATTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT188989 WP_003403184.1 NZ_CP069064:699938-700183 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT188989 NZ_CP090608:1971078-1971338 [Burkholderia cepacia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACACTGATGCTGCGGCCGGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References