Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 440390..441401 Replicon chromosome
Accession NZ_CP069064
Organism Mycobacterium tuberculosis strain N1202

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag JN149_RS01940 Protein ID WP_003401859.1
Coordinates 440390..440983 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag JN149_RS01945 Protein ID WP_003401860.1
Coordinates 441012..441401 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN149_RS01920 436039..437421 + 1383 WP_003898415.1 magnesium transporter -
JN149_RS01925 437433..438467 - 1035 WP_003910109.1 class II fructose-bisphosphate aldolase -
JN149_RS01930 438563..439246 + 684 WP_003401857.1 VTT domain-containing protein -
JN149_RS01935 439235..440365 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
JN149_RS01940 440390..440983 - 594 WP_003401859.1 zeta toxin family protein Toxin
JN149_RS01945 441012..441401 - 390 WP_003401860.1 hypothetical protein Antitoxin
JN149_RS01950 441482..442693 - 1212 WP_003401861.1 VWA domain-containing protein -
JN149_RS01955 442699..443301 - 603 WP_003898417.1 SRPBCC family protein -
JN149_RS01960 443315..444211 - 897 WP_003401863.1 MoxR family ATPase -
JN149_RS01965 444208..444801 - 594 WP_003401864.1 NTP transferase domain-containing protein -
JN149_RS01970 444798..445553 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T188985 WP_003401859.1 NZ_CP069064:c440983-440390 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T188985 NZ_CP090607:1473596-1474252 [Acinetobacter baumannii]
ATGGTTGGACGTAATTATAGTGATGTACTCAATCCGCAAAAGGCATTGATTTGGCGTATTGTGCATCGTGATAATATTCC
GTGGATATTAGAAAATGGCTTACATAGCAGCAATAGTCCAACACAATGTGTAAATTGGGTTCAGATTGGCAGTCCAGAAC
TGATTGAGAAAAGACAACTGCATCCTGTTCCTGTAGGGAAAAAGGGTGTGCTAAGTGACTATATTCCATTTTATTTCACA
CCATTTTCACCTATGCTGCTGAATATAAAGAGTGGCCGTGGCGGTGTACGTCAGCGTACTAATGATGAAATTGTTATTTT
AGTTTCTAGTTTGTATCAGCTACAGCAGCAGCAAATTCCTTTTGTTTTTACAAATAGTCATGCCTATTACCAATGGGCTG
AATTCTATACAGATTTATCTAGCTTAAATGAGATCGATTGGTCAATATTACAGGCAAGAGATTTTAAAAGAGATATGGAT
GATCCTGCGAAGTTTGAACGTTATCAAGCCGAAGCGTTAGTTCATCAACACTGCCCAACAAAAGTATTGATTGGGGTGAT
ATGTTATACTGAAACAGTTAAAGCTCAAATAGAACAGTGGCTGCAACAAGCAGATGTTAATATTCCTGTGCATGTGAGAC
AAGGGGTGTATTTCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT188985 WP_003401860.1 NZ_CP069064:c441401-441012 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT188985 NZ_CP090607:1474252-1475337 [Acinetobacter baumannii]
ATGATTCGTTATACAACAGGAAACTTATTAGATGCTCCTGTAGAAGCATTGGTAAATACCGTGAATACCGTTGGTGTAAT
GGGTAAAGGTATTGCTTTAATGTTTAAGGAGCGTTTTCCAAAAAACATGGCAGCTTATAGTCAAGCGTGCAAAGCTGGAC
AGGTTACAACTGGAAAAATGTTTGTGACTGAAACTAATGAGTTAATGGGCGCACGTTGGATTATTAACTTTCCAACTAAA
CAGCATTGGCGGGATAAATCCAAACTCCAATGGATTGAAGATGGTTTGCAGGATCTTAAAAAGTTCATCATTGATCATCA
AGTTAAATCTATTGCAATTCCACCATTAGGTGCGGGTAATGGTGGGTTAGAGTGGAGTCGTGTTAAATCAAAAATTGAGA
CAGAATTATCCGATTTAGAGTATGTGGATATTTTGATTTTTGAACCAACCACACAGTATCAAAACGTGGCAAAGAAAATA
GGTGTATCACAACTTACACCAGCACGAGCCATGATTGCAGAGTTAGTACGTCGTTATTGGGTATTGGGGATTGAATGTAG
TCTATTAGAAATCCAAAAACTGGCATGGTTTTTACAGCGAGTTATTGAGCAAAAACAATTACCAAATGAATTGAAGCTTA
ATTTTCAGGCGAACTATTATGGTCCTTATGCTTCTAATTTAGACCATTTGTTGAATGCAATGGATGGTAGCTATCTCAAA
TCGGACAAGCGAATTCCTGATTGTGACCCCTTAGATGTGATTTGGTTCAATGATCAGCAAAAAAGTAAAGTTCAAGGTTA
TCTGATTAGTGAAGCAAAAGAGTATATGGCTGCTGTAGAAGGAGCTGCAACATTGATAGAGGGTTTTGAATCACCATTTG
GTATGGAGCTTTTGGCAACAGTAGATTGGCTTATCTATAAGGAAGGTTATCAACCTAATGTTGAATCAATTCAAGAAGGG
TTAGCGAATTGGAGTGCAGGTGAGCGTTGGGCAAGACGGAAATCTGATTTATTCAAAGCAGAGCATATTCAATTTGCATT
ACAAAAATTAGATGGTTTTGCTTATTTTCATACAGATGTAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References