Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2413432..2413961 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN150_RS11285 Protein ID WP_003411124.1
Coordinates 2413432..2413749 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN150_RS11290 Protein ID WP_003411127.1
Coordinates 2413746..2413961 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS11255 2408569..2409645 + 1077 WP_003411110.1 hypothetical protein -
JN150_RS11260 2409642..2409923 + 282 WP_003411112.1 DUF5703 family protein -
JN150_RS11265 2409959..2411032 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN150_RS11270 2411037..2411567 - 531 WP_050069432.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN150_RS11275 2411615..2412961 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN150_RS11285 2413432..2413749 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN150_RS11290 2413746..2413961 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN150_RS11295 2414216..2415274 + 1059 WP_078800661.1 phosphoribosyltransferase family protein -
JN150_RS11300 2415404..2415760 - 357 WP_003411130.1 hypothetical protein -
JN150_RS11305 2415855..2416637 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN150_RS11310 2416905..2417195 - 291 WP_003900476.1 YggT family protein -
JN150_RS11315 2417357..2418013 - 657 WP_003411133.1 cell division protein SepF -
JN150_RS11320 2418079..2418855 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T188962 WP_003411124.1 NZ_CP069063:c2413749-2413432 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T188962 NZ_CP090596:c206504-206325 [Pectobacterium aroidearum]
ATGGATAGCAGGACGTTAATCGCAGAAATCAAGGCCGATGGGTGGGAGCTGATACGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGATTAGTCACAATCCCCCACCCCAAGAAGGATTTACCAATAGGTACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT188962 WP_003411127.1 NZ_CP069063:c2413961-2413746 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT188962 NZ_CP090596:c206297-205887 [Pectobacterium aroidearum]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCACGCATACGGCGTAACAGTACCAGATTTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCTATCGCAAACGCTAAAGAAGCGATTACCGGACATATCGAGCTACTGGTTGAGA
TGGGTCAGGATATTCCCACCGTATCAACAGTAGGTCAGTTGGCAAAAGGGTCTGAGTATGCAGGGTACACGTGGGCGGTT
GTTGATATTGATGTAACTCGTTTAATGGGCGGCTCAGAAAAAATTAACGTTACATTGCCCAAATCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAATCCAGAATTTAAAAGTCGTTCGGGTTTTCTTGCACAGGCGGCATTAGAGCGAATTTCGT
CTTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References