188958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2265663..2266289 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag JN150_RS10595 Protein ID WP_003410075.1
Coordinates 2265891..2266289 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag JN150_RS10590 Protein ID WP_003911750.1
Coordinates 2265663..2265890 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS10580 2263702..2264046 - 345 WP_003410065.1 ferredoxin family protein -
JN150_RS10585 2264235..2265404 - 1170 WP_003899126.1 ATP-binding protein -
JN150_RS10590 2265663..2265890 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN150_RS10595 2265891..2266289 + 399 WP_003410075.1 PIN domain nuclease Toxin
JN150_RS10600 2266472..2266903 - 432 WP_244734966.1 MarR family winged helix-turn-helix transcriptional regulator -
JN150_RS10605 2267004..2267438 + 435 WP_003914358.1 DUF1398 domain-containing protein -
JN150_RS10610 2267875..2268054 - 180 Protein_2095 hypothetical protein -
JN150_RS10615 2268142..2268762 + 621 WP_003410086.1 IS110 family transposase -
JN150_RS10620 2268716..2269306 + 591 WP_003899131.1 IS110 family transposase -
JN150_RS10625 2269434..2270690 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T188958 WP_003410075.1 NZ_CP069063:2265891-2266289 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T188958 NZ_CP090595:c3171091-3170771 [Pectobacterium aroidearum]
ATGCAAGCAACACCAGCAATCCCGTCAGGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGTTGAC
CTACCTTATGGAAAAACACTACGGCCTGACACTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACGTTGGTCAATGCCGTCAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGATCGCAACGGCTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCCGTTGATGTTCTCCGTGCCAGACGTGCTACTGGCTTGCTCAAGACATA
A

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT188958 WP_003911750.1 NZ_CP069063:2265663-2265890 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT188958 NZ_CP090595:c3171496-3171161 [Pectobacterium aroidearum]
ATGTCATCAGTAGAGGCCCCGGAATGGGGATTAAAGTGTGCTGTCACGCCGCGATTCGGAGCCAGGCTGGTCCAGGAAGG
ACACCGCCTGCATTATCTGGAAGACCGGGCCAGCATTGTCGGTACGTTCAGCAAAACAGAAGCCCGCAATCTGGAGCGTT
GCTTCCCTGAGCTGATTAAGCAGTTGGAGCAGAAACTACGAACGGGAGAACTGAACCCCTGTCAGCAAGGCTGCATCGTG
CTGCATTGCAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGCTACGTGTATATTGCTATTTATCCCTCTTC
AGCGGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References