Detailed information of TA system TA188945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1389125..1389684
• Replicon: chromosome
• Accession: NZ_CP069063
• Organism: Mycobacterium tuberculosis strain N3913

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN150_RS06630
• Protein ID: WP_050069449.1
• Coordinates: 1389125..1389418 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JN150_RS06635
• Protein ID: WP_003406322.1
• Coordinates: 1389415..1389684 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN150_RS06605	1384724..1384984	+	261	WP_050069455.1	type II toxin-antitoxin system antitoxin VapB33	-
JN150_RS06610	1384981..1385412	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JN150_RS06615	1385435..1387117	-	1683	Protein_1306	PE family protein	-
JN150_RS06620	1387297..1388157	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
JN150_RS06625	1388238..1389068	-	831	WP_050069448.1	SDR family NAD(P)-dependent oxidoreductase	-
JN150_RS06630	1389125..1389418	-	294	WP_050069449.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JN150_RS06635	1389415..1389684	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN150_RS06640	1389797..1393492	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JN150_RS06645	1393634..1394422	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T188945 WP_050069449.1 NZ_CP069063:c1389418-1389125 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIL
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T188945 NZ_CP090594:4297902-4298153 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAGAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCTCTGGAAGAGTATAATTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT188945 WP_003406322.1 NZ_CP069063:c1389684-1389415 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT188945 NZ_CP090594:4298150-4298404 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGTAGAACACCTTTTGAGGGAAAAGGAAAACCGGAGCCACTTAAACATAACCTCGCTG
GTTTCTGGTCGCGCCGTATAACCGAAGAGCATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Structures

Antitoxin

• AlphaFold DB: G0THS2