Detailed information of TA system TA188944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384724..1385412
• Replicon: chromosome
• Accession: NZ_CP069063
• Organism: Mycobacterium tuberculosis strain N3913

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: JN150_RS06610
• Protein ID: WP_003406304.1
• Coordinates: 1384981..1385412 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN150_RS06605
• Protein ID: WP_050069455.1
• Coordinates: 1384724..1384984 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN150_RS06585	1380301..1381125	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
JN150_RS06590	1381130..1382311	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
JN150_RS06595	1382388..1383488	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
JN150_RS06600	1383659..1384648	+	990	WP_003406301.1	malate dehydrogenase	-
JN150_RS06605	1384724..1384984	+	261	WP_050069455.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
JN150_RS06610	1384981..1385412	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN150_RS06615	1385435..1387117	-	1683	Protein_1306	PE family protein	-
JN150_RS06620	1387297..1388157	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
JN150_RS06625	1388238..1389068	-	831	WP_050069448.1	SDR family NAD(P)-dependent oxidoreductase	-
JN150_RS06630	1389125..1389418	-	294	WP_050069449.1	type II toxin-antitoxin system mRNA interferase RelE	-
JN150_RS06635	1389415..1389684	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T188944 WP_003406304.1 NZ_CP069063:1384981-1385412 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T188944 NZ_CP090594:4217307-4218236 [Pectobacterium aroidearum]
ATGGATCATCGTGATATTTATGCCCGACAGGTCAAGCTGTTAATGACCGCCCTGCCGTATGTGGCGAAAGAACCCTGTTT
CGCACTGAAAGGCGGCACCGCAATTAATTTATTTGTGCAGGATTTTCCTCGTCTATCGGTAGATATCGATCTGGTTTATC
AAACCTTCATAGATCGTGATACAGACCTAATCGCTATTGACGATGCATTGATGCGTATTACGGAATCGCTGAATGGCAGA
CAGGGGCTCACAGCGATCCAGCAGGAGAATAAAGCCGATGAAAAACGCATCATCGTTAATACCGCTGATGCGCAGATAAA
GATTGAAGTCAGCCCGGTCTGGCGTGGACTGCTGTTGCCCCCAGCAGAAATGCCGGTATGTGAGCAGGTGGAAATGGAAT
ACGGCTTCACCACCATGAGCGTTGTCTCTCTGGCAGATCTTTACGGCGGCAAAATCTGCGCTGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGATGTACTGAATATGCTAGAAAAACCGTGCCTAACGCGTGAGATTTTTGATGGTTTTCTTTGCTA
TCTGGCAGGACATCCTCGCCCTATTGCCGAACTACTGGCACCGAATTGGGACACATCGCGGATCGCCACACTATACGCCC
AGGAATTTTCAGGCATGACGCAGCAGGAAACCTCACTGGAATCGCTGTTATCTGTAGCGACTCTACTGCCGCAGGCGTTG
AAATCTCATTTCACCGCTCAGGACCGGCAATTCTTACTCAGCTATAAGCAAAACAACCCTGACTGGTCGCTGTATCGCTA
TCCTGATATTCAACATCTTCCCGCCATTCGCTGGAAACAGCGGAATTTATCGGCTTTACATGCTAAAAATCCGGCCAAAT
TTAGCGCGGCAGTAGGTAAGCTTGAGAAGGTTCTGGAACAACATTTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9908.23 Da
• Isoelectric Point: 6.4693

>AT188944 WP_050069455.1 NZ_CP069063:1384724-1384984 [Mycobacterium tuberculosis]
MRTTCTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT188944 NZ_CP090594:4216538-4217320 [Pectobacterium aroidearum]
TTGACAAATTATCTAAACTGGCTGATGCAAAACACCCTGCCCGGTCAGGTGTTGCTACAGTCATGGCTTACCCGCAACGG
CATAGACCGTAAGCTCTCTTACGTCTATGTCCAAAACGGTTGGCTCAGGCGGATCGCTCACGGCGTTTACTGCCGGACGG
GTCGTGAACCAGACTGGGTGGATGCGGTTTACTGCCTGCAAACTCAATGGGAGAAACCTGTGCGGGTAGCAGGGCTGACC
AGCCTTGCGCTACAGGGCTATTCCCATTATACCGAACTGGGTAAACCTCAAATTTGGCTCACGCTCCCGGCTTACATAAA
GCTGCCGGGATGGTTCACCGCCTTTAAACCATCCGCCACCTTTGTCGTGCTCTATACATCAGGCCTGTCGGTTGATGTGA
TGCCACTCACGACAGAACTGAGAATCGGCGATCGGCGGCTGACTGGCAGCATGCCAGAACTTGCCGCATATGAAATCGCC
AGCGGCGTTCCCGCACAAATATCGTTTGAGCATGCAGATGCATTGTTTCAGGGGCTGAACCTTCTCAGTCCGCGTAAATT
ACAGGCACTGCTCTATGCCAGCCATTCGGTAAAAACCAACAGGGTGATGCTCTACCTTGCCCAGCGCAATGGACATCCTT
ATTTTCAGTATCTCGATAAAAGTGGTATAGAAACAGGCGCTGGAAAGCGGCAAATTGTCCCCGGTGGCTGGCTGGAACCG
GATTACCAGATCACGGTTCCCAGGGAGTTTAAATCGGAAGGAGTCGAAGATGGATCATCGTGA

Structures

Toxin

• AlphaFold DB: G0THR7