Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 719368..720017 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN150_RS03285 Protein ID WP_003403236.1
Coordinates 719622..720017 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN150_RS03280 Protein ID WP_003403235.1
Coordinates 719368..719622 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS03255 714494..714577 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
JN150_RS03260 714596..715677 + 1082 Protein_646 galactose-1-phosphate uridylyltransferase -
JN150_RS03265 715674..716765 + 1092 WP_003900977.1 galactokinase -
JN150_RS03270 717160..718317 + 1158 WP_003903091.1 hypothetical protein -
JN150_RS03275 718328..719275 + 948 WP_050069287.1 DUF732 domain-containing protein -
JN150_RS03280 719368..719622 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN150_RS03285 719622..720017 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN150_RS03290 720111..720851 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN150_RS03295 720983..721243 + 261 WP_050069288.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN150_RS03300 721240..721647 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN150_RS03305 721719..722870 - 1152 WP_050069289.1 FIST N-terminal domain-containing protein -
JN150_RS03310 722963..724690 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T188932 WP_003403236.1 NZ_CP069063:719622-720017 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T188932 NZ_CP090593:4298166-4298420 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGTAGAACACCTTTTGAGGGAAAAGGAAAACCGGAGCCACTTAAACATAACCTCGCTG
GTTTCTGGTCGCGCCGTATAACCGAAGAGCATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT188932 WP_003403235.1 NZ_CP069063:719368-719622 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT188932 NZ_CP090593:4297918-4298169 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAGAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCTCTGGAAGAGTATAATTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References