188931

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 713740..714365 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN150_RS03250 Protein ID WP_003403218.1
Coordinates 713964..714365 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN150_RS03245 Protein ID WP_003403213.1
Coordinates 713740..713967 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS03220 708919..709140 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN150_RS03225 709282..709887 + 606 WP_003898526.1 hypothetical protein -
JN150_RS03230 709906..712473 - 2568 WP_050069302.1 SEC-C metal-binding domain-containing protein -
JN150_RS03235 712557..713306 + 750 WP_003898528.1 hypothetical protein -
JN150_RS03240 713303..713545 + 243 WP_003403210.1 hypothetical protein -
JN150_RS03245 713740..713967 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN150_RS03250 713964..714365 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN150_RS03255 714494..714577 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
JN150_RS03260 714596..715677 + 1082 Protein_646 galactose-1-phosphate uridylyltransferase -
JN150_RS03265 715674..716765 + 1092 WP_003900977.1 galactokinase -
JN150_RS03270 717160..718317 + 1158 WP_003903091.1 hypothetical protein -
JN150_RS03275 718328..719275 + 948 WP_050069287.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T188931 WP_003403218.1 NZ_CP069063:713964-714365 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T188931 NZ_CP090593:4297918-4298169 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGCGAAGCCCGACAGAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGTGAAGCCTGCGTGCTGATGTCTCTGGAAGAGTATAATTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT188931 WP_003403213.1 NZ_CP069063:713740-713967 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT188931 NZ_CP090593:4298166-4298420 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGTAGAACACCTTTTGAGGGAAAAGGAAAACCGGAGCCACTTAAACATAACCTCGCTG
GTTTCTGGTCGCGCCGTATAACCGAAGAGCATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References