188930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 706202..706845 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN150_RS03200 Protein ID WP_003403187.1
Coordinates 706444..706845 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN150_RS03195 Protein ID WP_003403184.1
Coordinates 706202..706447 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS03160 701482..702012 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN150_RS03165 701996..702691 - 696 WP_214443079.1 response regulator transcription factor -
JN150_RS03170 702814..703125 + 312 WP_003403164.1 hypothetical protein -
JN150_RS03175 703197..704147 + 951 WP_050069301.1 DUF1259 domain-containing protein -
JN150_RS03180 704388..704972 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN150_RS03185 704974..705684 + 711 Protein_631 IS607 family element RNA-guided endonuclease TnpB -
JN150_RS03190 705687..706157 + 471 WP_003898523.1 hypothetical protein -
JN150_RS03195 706202..706447 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN150_RS03200 706444..706845 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN150_RS03205 706836..707015 + 180 Protein_635 hypothetical protein -
JN150_RS03210 707433..707630 - 198 WP_003403191.1 hypothetical protein -
JN150_RS03215 707710..708867 - 1158 WP_003403193.1 hypothetical protein -
JN150_RS03220 708919..709140 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN150_RS03225 709282..709887 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T188930 WP_003403187.1 NZ_CP069063:706444-706845 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T188930 NZ_CP090593:4217323-4218252 [Pectobacterium aroidearum]
ATGGATCATCGTGATATTTATGCCCGACAGGTCAAGCTGTTAATGACCGCCCTGCCGTATGTGGCGAAAGAACCCTGTTT
CGCACTGAAAGGCGGCACCGCAATTAATTTATTTGTGCAGGATTTTCCTCGTCTATCGGTAGATATCGATCTGGTTTATC
AAACCTTCATAGATCGTGATACAGACCTAATCGCTATTGACGATGCATTGATGCGTATTACGGAATCGCTGAATGGCAGA
CAGGGGCTCACAGCGATCCAGCAGGAGAATAAAGCCGATGAAAAACGCATCATCGTTAATACCGCTGATGCGCAGATAAA
GATTGAAGTCAGCCCGGTCTGGCGTGGACTGCTGTTGCCCCCAGCAGAAATGCCGGTATGTGAGCAGGTGGAAATGGAAT
ACGGCTTCACCACCATGAGCGTTGTCTCTCTGGCAGATCTTTACGGCGGCAAAATCTGCGCTGCGCTTGACCGCCAGCAT
CCGCGCGATCTGTTTGATGTACTGAATATGCTAGAAAAACCGTGCCTAACGCGTGAGATTTTTGATGGTTTTCTTTGCTA
TCTGGCAGGACATCCTCGCCCTATTGCCGAACTACTGGCACCGAATTGGGACACATCGCGGATCGCCACACTATACGCCC
AGGAATTTTCAGGCATGACGCAGCAGGAAACCTCACTGGAATCGCTGTTATCTGTAGCGACTCTACTGCCGCAGGCGTTG
AAATCTCATTTCACCGCTCAGGACCGGCAATTCTTACTCAGCTATAAGCAAAACAACCCTGACTGGTCGCTGTATCGCTA
TCCTGATATTCAACATCTTCCCGCCATTCGCTGGAAACAGCGGAATTTATCGGCTTTACATGCTAAAAATCCGGCCAAAT
TTAGCGCGGCAGTAGGTAAGCTTGAGAAGGTTCTGGAACAACATTTTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT188930 WP_003403184.1 NZ_CP069063:706202-706447 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT188930 NZ_CP090593:4216554-4217336 [Pectobacterium aroidearum]
TTGACAAATTATCTAAACTGGCTGATGCAAAACACCCTGCCCGGTCAGGTGTTGCTACAGTCATGGCTTACCCGCAACGG
CATAGACCGTAAGCTCTCTTACGTCTATGTCCAAAACGGTTGGCTCAGGCGGATCGCTCACGGCGTTTACTGCCGGACGG
GTCGTGAACCAGACTGGGTGGATGCGGTTTACTGCCTGCAAACTCAATGGGAGAAACCTGTGCGGGTAGCAGGGCTGACC
AGCCTTGCGCTACAGGGCTATTCCCATTATACCGAACTGGGTAAACCTCAAATTTGGCTCACGCTCCCGGCTTACATAAA
GCTGCCGGGATGGTTCACCGCCTTTAAACCATCCGCCACCTTTGTCGTGCTCTATACATCAGGCCTGTCGGTTGATGTGA
TGCCACTCACGACAGAACTGAGAATCGGCGATCGGCGGCTGACTGGCAGCATGCCAGAACTTGCCGCATATGAAATCGCC
AGCGGCGTTCCCGCACAAATATCGTTTGAGCATGCAGATGCATTGTTTCAGGGGCTGAACCTTCTCAGTCCGCGTAAATT
ACAGGCACTGCTCTATGCCAGCCATTCGGTAAAAACCAACAGGGTGATGCTCTACCTTGCCCAGCGCAATGGACATCCTT
ATTTTCAGTATCTCGATAAAAGTGGTATAGAAACAGGCGCTGGAAAGCGGCAAATTGTCCCCGGTGGCTGGCTGGAACCG
GATTACCAGATCACGGTTCCCAGGGAGTTTAAATCGGAAGGAGTCGAAGATGGATCATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References