Detailed information of TA system TA188929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 700112..700758
• Replicon: chromosome
• Accession: NZ_CP069063
• Organism: Mycobacterium tuberculosis strain N3913

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ88
• Locus tag: JN150_RS03145
• Protein ID: WP_003403137.1
• Coordinates: 700112..700525 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ89
• Locus tag: JN150_RS03150
• Protein ID: WP_003403139.1
• Coordinates: 700522..700758 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN150_RS03125	696195..697745	+	1551	WP_050069300.1	MlaD family protein	-
JN150_RS03130	697797..698189	-	393	WP_003403122.1	type II toxin-antitoxin system toxin ribonuclease C4	-
JN150_RS03135	698186..698443	-	258	WP_003403125.1	type II toxin-antitoxin system antitoxin VapB4	-
JN150_RS03140	698626..699861	-	1236	WP_003403128.1	ATP-binding protein	-
JN150_RS03145	700112..700525	-	414	WP_003403137.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN150_RS03150	700522..700758	-	237	WP_003403139.1	type II toxin-antitoxin system antitoxin VapB27	Antitoxin
JN150_RS03155	700862..701368	-	507	WP_003900973.1	two component system sensor kinase HK1	-
JN150_RS03160	701482..702012	-	531	WP_003917320.1	two component system sensor kinase HK2	-
JN150_RS03165	701996..702691	-	696	WP_214443079.1	response regulator transcription factor	-
JN150_RS03170	702814..703125	+	312	WP_003403164.1	hypothetical protein	-
JN150_RS03175	703197..704147	+	951	WP_050069301.1	DUF1259 domain-containing protein	-
JN150_RS03180	704388..704972	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
JN150_RS03185	704974..705684	+	711	Protein_631	IS607 family element RNA-guided endonuclease TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-126)

Antitoxin

• SpoVT-AbrB domain (3-43)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14786.14 Da
• Isoelectric Point: 8.1405

>T188929 WP_003403137.1 NZ_CP069063:c700525-700112 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Nucleotide

• Length: 414 bp

>T188929 NZ_CP090593:c3972550-3972176 [Pectobacterium aroidearum]
ATGCAACTGCTTTCATTGATTGTGCATGGCCTATTAGTATTGCTCATTCTTCTGGCGCCGTGGCCGGACGGCTATGCATG
GCTGTGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTATCCGTAGCCAAAGGAATATCAAATCCCGGCAGGGGGAAA
TCGTTTTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAGGAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAAAAT
GGCGTATTGCTGTCATTGCAGGCAGTGAACGGTAAAGACAGACAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGA
CGAATGGCGTCATCTGCGTCAGCTTCTTTTGCAGCAGAAAAACTGGGCGAGATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8212.41 Da
• Isoelectric Point: 5.0351

>AT188929 WP_003403139.1 NZ_CP069063:c700758-700522 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Nucleotide

• Length: 237 bp

>AT188929 NZ_CP090593:c3972836-3972570 [Pectobacterium aroidearum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGGGGTATGCGTGAGTTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTACGACACACTCAGTGACAGCGATAAGCGCACGTTTGTGCGCCTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCGAGCCGAAAGACGGAGAGCTGAAACGCATGATTTCTCTTATTCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: G0TQ88

Antitoxin

• AlphaFold DB: G0TQ89