Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 697797..698443 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag JN150_RS03130 Protein ID WP_003403122.1
Coordinates 697797..698189 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag JN150_RS03135 Protein ID WP_003403125.1
Coordinates 698186..698443 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS03115 693460..694985 + 1526 Protein_617 virulence factor Mce family protein -
JN150_RS03120 695048..696190 + 1143 WP_003911253.1 virulence factor Mce family protein -
JN150_RS03125 696195..697745 + 1551 WP_050069300.1 MlaD family protein -
JN150_RS03130 697797..698189 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
JN150_RS03135 698186..698443 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
JN150_RS03140 698626..699861 - 1236 WP_003403128.1 ATP-binding protein -
JN150_RS03145 700112..700525 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
JN150_RS03150 700522..700758 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
JN150_RS03155 700862..701368 - 507 WP_003900973.1 two component system sensor kinase HK1 -
JN150_RS03160 701482..702012 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN150_RS03165 701996..702691 - 696 WP_214443079.1 response regulator transcription factor -
JN150_RS03170 702814..703125 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T188928 WP_003403122.1 NZ_CP069063:c698189-697797 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T188928 NZ_CP090593:c3778232-3777744 [Pectobacterium aroidearum]
ATGATCTCCGCTCCTGAGCCACTCCACGCCGAACATGTACTATCTTCATTCTGTTGCGGCGTGGAGTCCATGGACAACTG
GCTAAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCGCGAACTTTCGTCAGTTGTGATGGCTCAAAAGTGCTGG
CGTATTACTCATTGGCTTCCAGTGCCGTAGCAACGAATGCCGCTCCCGGACGTTTTCGTCGCAATATGCCCGATCCAATT
CCGGTGGTAGTGCTGGGTCGTCTGGCGGTGGATAAATCATTACATGGTCAGGGCGTTGGCCGAGCGCTGGTGCGCGATGT
CGGGCTGCGGGTGATTCAGGTGGCGGATACTATCGGCATTCGCGGGATGCTGGTTCATGCGTTGTCTGATGAAGCACGGG
AATTTTACCTACGCGTGGGGTTTGAGCCTTCGCCGATAGATCCGATGCTGTTGATGGTGACGTTGGGGGATTTGGTGGGG
AGTGTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT188928 WP_003403125.1 NZ_CP069063:c698443-698186 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT188928 NZ_CP090593:c3778522-3778229 [Pectobacterium aroidearum]
ATGCCAGCGACGAACAGCGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAACCCGCAGAACGGGATCTGATTGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTTGAGGCTGCGCGTGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTACTCGCTTGGATCAGGCTCCTTCCCCGAAT
GCCGCGCTGCGCAAAACCATGCAAACGTCTGCACCGTGGGAACAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References