Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 447017..448028 Replicon chromosome
Accession NZ_CP069063
Organism Mycobacterium tuberculosis strain N3913

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag JN150_RS01935 Protein ID WP_003401859.1
Coordinates 447017..447610 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag JN150_RS01940 Protein ID WP_003401860.1
Coordinates 447639..448028 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN150_RS01915 442666..444048 + 1383 WP_003898415.1 magnesium transporter -
JN150_RS01920 444060..445094 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
JN150_RS01925 445190..445873 + 684 WP_003401857.1 VTT domain-containing protein -
JN150_RS01930 445862..446992 - 1131 WP_050069107.1 glycoside hydrolase family 76 protein -
JN150_RS01935 447017..447610 - 594 WP_003401859.1 zeta toxin family protein Toxin
JN150_RS01940 447639..448028 - 390 WP_003401860.1 hypothetical protein Antitoxin
JN150_RS01945 448109..449320 - 1212 WP_003401861.1 VWA domain-containing protein -
JN150_RS01950 449326..449928 - 603 WP_003898417.1 SRPBCC family protein -
JN150_RS01955 449942..450838 - 897 WP_003401863.1 MoxR family ATPase -
JN150_RS01960 450835..451428 - 594 WP_003401864.1 NTP transferase domain-containing protein -
JN150_RS01965 451425..452180 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T188925 WP_003401859.1 NZ_CP069063:c447610-447017 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T188925 NZ_CP090593:2899433-2899717 [Pectobacterium aroidearum]
ATGGAAATTAAATGGCTGCGTAAAGCCGCGGCCAATTTGGAAGCCGAATACCTCTATATCGCGCAAGACGATCCACAGGC
TGCCAGCCAGTTCGTAGATGAAGTCCAAAGATTAACGGAATTACTACCGCAACAGCCAGCAATGGGAAGGCCAGGCCGTG
TGCCAGGAACGCGTGAGCTGGTGTTAACGCACTATCCCTACATCATCCCCTACCGTGTGAAAGATAATATGCTCCAGATT
CTGCGCATCTTTCATACGCACAGACGTTTACCATCAAAATGGTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT188925 WP_003401860.1 NZ_CP069063:c448028-447639 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT188925 NZ_CP090593:2899764-2900003 [Pectobacterium aroidearum]
ATGGGTAATGTTACTTTCCGTATCGGTGACGATCTTAAAAAGCGCTCTTATGCAGCGCTTAAGAAACTGGGTATTACGCC
TTCTGAAGCATTTCGCCTCACGTTGGAATACATTGCTGAAAATGAAAGACTCCCATTTAAACAAAAGTTACTCAATGATG
AAGACGTAGAATTAGTTGAAGTTGTCCGTGAACGTCTTCGCAACCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References